Pumilio 1 Activators
Pumilio 1 activators encompass a diverse group of chemical agents that enhance the biological activity of Pumilio 1 (PUM1), a member of the Pumilio family of RNA-binding proteins. PUM1 is known for its role in post-transcriptional regulation, where it typically binds to specific sequences in the 3'-untranslated regions (3'-UTRs) of target mRNAs, influencing their stability and translation. The interaction between PUM1 and mRNA is mediated by the Pumilio homology domain (PUM-HD), a conserved region that is responsible for sequence-specific RNA binding.
The activators of PUM1 function through several potential mechanisms. Some might directly interact with the protein, possibly altering its conformation in a way that enhances its affinity for RNA or its ability to repress translation. Others might act indirectly, for example, by modulating signaling pathways that affect PUM1's expression levels or by inhibiting negative regulators of PUM1, thereby increasing its functional presence within the cell. The precise mechanism by which these activators exert their effects can vary widely depending on their chemical structure and the cellular context. For instance, certain activators might prevent the phosphorylation of PUM1, a post-translational modification that could influence its activity or localization. Alternatively, some compounds may promote the interaction of PUM1 with cofactors that are necessary for its full activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that initiates DNA damage, subsequently activating the ATM/ATR pathway. Pumilio 1, an RNA-binding protein, is upregulated in response to this DNA damage, thereby modulating its function. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits the NF-kB pathway by blocking IκBα phosphorylation. This blockage of the pathway alters the activity of Pumilio 1, as it is a participant in this pathway. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor, increasing the stability and activity of Pumilio 1 by preventing its degradation. | ||||||
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $82.00 $163.00 $296.00 $2050.00 $5110.00 $16330.00 | 51 | |
Rottlerin selectively inhibits PKC delta, which can modulate the activity of Pumilio 1, as it is involved in the PKC delta pathway. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 selectively inhibits ROCK I and II, leading to modulation of Pumilio 1, which is part of this pathway. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is an inhibitor of TGF-beta type I receptor ALK5 kinase, ALK4, and ALK7, which modulates the TGF-beta pathway, thus influencing Pumilio 1 activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, which modulates the JNK pathway and thereby influences Pumilio 1 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an MEK inhibitor, which modulates the ERK pathway by inhibiting MEK1 and MEK2. This modulation influences Pumilio 1 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases cAMP levels and subsequently activates PKA. This activation of PKA leads to phosphorylation and activation of Pumilio 1. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2'-deoxycytidine, a DNA methyltransferase inhibitor, induces DNA hypomethylation. This alteration in methylation can modulate Pumilio 1, as its function is influenced by the DNA methylation status | ||||||