PTα Activators
PTα Activators are chemicals that can modulate the expression or activity of PTα (prothymosin alpha). These chemicals primarily operate through three major pathways: the cAMP-PKA-CREB pathway, the PI3K/AKT pathway, and the p53 pathway. In the cAMP-PKA-CREB pathway, chemicals such as Forskolin, 8-Br-cAMP, Isoproterenol, H89, and IBMX can increase intracellular cAMP levels. Elevated cAMP activates PKA, which then phosphorylates and activates CREB. Activated CREB, as a transcription factor, can then upregulate the expression of PTα.
In the PI3K/AKT pathway, chemicals such as EGF and LY294002 can activate the pathway, leading to the activation of AKT. Activated AKT can phosphorylate and activate CREB, which can increase the transcription of PTα, hence upregulating its expression. In the p53 pathway, chemicals like Etoposide, Cisplatin, Nutlin-3, and Doxorubicin activate the pathway. Activated p53, as a transcription factor, can upregulate the transcription of PTα.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin stimulates adenylate cyclase, leading to an increase in intracellular cAMP levels. This increase in cAMP activates PKA, which phosphorylates and activates CREB. CREB, as a transcription factor, can then upregulate the expression of PTα. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analogue. It activates PKA, which phosphorylates and activates CREB. Activated CREB can upregulate PTα expression. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a β-adrenergic receptor agonist that increases cAMP levels, activating PKA. PKA phosphorylates CREB, leading to an increase in PTα expression. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H89 is a PKA inhibitor that can increase intracellular cAMP levels under certain conditions. This can activate PKA, leading to the phosphorylation of CREB and increased PTα expression. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor. It increases cAMP levels, thereby activating PKA. PKA then phosphorylates CREB, leading to increased PTα expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can activate the PI3K/AKT pathway under certain conditions. Activated AKT phosphorylates CREB, leading to increased PTα expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a DNA topoisomerase II inhibitor that can activate the p53 pathway. Activated p53 can upregulate the transcription of PTα. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin is a DNA-damaging agent that can activate the p53 pathway. Activated p53 can upregulate the transcription of PTα. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3 is a MDM2 inhibitor that can activate the p53 pathway. Activated p53 can upregulate the transcription of PTα. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin is a DNA intercalating agent that can activate the p53 pathway. Activated p53 can upregulate the transcription of PTα. | ||||||