PRPF38A Inhibitors
PRPF38A, or Pre-mRNA-processing factor 38A, is an integral part of the pre-mRNA splicing machinery, a critical process in gene expression. As a component of the spliceosome, PRPF38A aids in the removal of introns from pre-mRNA and the correct assembly of exons to produce mature mRNA. This splicing event is essential for generating functional proteins, as it ensures the accurate interpretation of genetic information. PRPF38A plays a specific role in stabilizing and assembling the early spliceosomal complexes, making it key in the early stages of splicing. Its interaction with other proteins and RNAs within the spliceosome underscores its role in ensuring the precision and efficiency of this complex, dynamic process.
Anomalies in PRPF38A function or expression can lead to splicing errors, resulting in the production of defective mRNA transcripts. These aberrant splicing events are associated with several diseases, highlighting the importance of PRPF38A in maintaining normal cellular function. Particularly, dysregulation of PRPF38A has been implicated in the pathogenesis of diseases such as cancer, where splicing defects contribute to abnormal gene expression and cellular behavior. Understanding the molecular mechanisms by which PRPF38A operates within the spliceosome provides valuable insights into the broader regulatory processes of gene expression and offers potential avenues for addressing splicing-related disorders.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin is a potent inhibitor of RNA polymerase II, which is responsible for transcribing mRNA. By inhibiting this enzyme, the synthesis of PRPF38A mRNA may be reduced. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA synthesis. This can potentially reduce the synthesis of PRPF38A mRNA. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB inhibits RNA polymerase II, which could lead to decreased synthesis of PRPF38A mRNA. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin is an adenosine analogue that can terminate RNA chain elongation, potentially impacting PRPF38A mRNA synthesis. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Pladienolide B targets the spliceosome and can inhibit splicing, potentially affecting the function of PRPF38A. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
Isoginkgetin is a natural biflavonoid that has been shown to inhibit pre-mRNA splicing, which could impact PRPF38A's role. | ||||||
Herboxidiene | 142861-00-5 | sc-506378 | 1 mg | $1009.00 | ||
Herboxidiene targets the spliceosome and inhibits splicing, potentially affecting the function of PRPF38A. | ||||||
8-Azaguanine | 134-58-7 | sc-207194 sc-207194A | 1 g 5 g | $84.00 $212.00 | 1 | |
This purine analogue can be incorporated into RNA, potentially affecting RNA stability and processing, which might impact PRPF38A expression indirectly. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
Ribavirin is a guanosine analogue that can impact RNA metabolism and might indirectly affect PRPF38A expression. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol inhibits cyclin-dependent kinases and can affect RNA polymerase II phosphorylation, potentially reducing PRPF38A mRNA synthesis. | ||||||