PRPF38A Activators
Pre-mRNA processing factor 38A (PRPF38A) is a critical component of the human spliceosome, an elaborate ribonucleoprotein complex responsible for the removal of non-coding sequences (introns) from pre-mRNA transcripts. This splicing process is essential for converting pre-mRNA into mature mRNA, which can then be translated into proteins. PRPF38A specifically associates with the U4/U6-U5 tri-snRNP (small nuclear ribonucleoproteins) complex, which is pivotal in the splicing cycle.
The function of PRPF38A is to facilitate the proper assembly of the spliceosome and to ensure the accuracy of splicing. It aids in the alignment of the spliceosome with the correct regions of the pre-mRNA, thereby influencing the selection of exon and intron boundaries. This is a highly regulated process, crucial for generating the diverse repertoire of mRNA transcripts through alternative splicing, which in turn leads to protein diversity.Mutations or dysregulation of PRPF38A and other splicing factors are linked to various diseases, including retinitis pigmentosa, a form of hereditary blindness, showcasing the importance of precise splicing in cellular function and development. PRPF38A is also of interest in cancer research, as aberrant splicing events can contribute to tumorigenesis and cancer progression.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As an HDAC inhibitor, Trichostatin A may enhance transcription of various genes, possibly including PRPF38A. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methylation inhibitor that may upregulate genes involved in RNA processing by altering chromatin structure. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
May influence gene expression patterns, potentially affecting PRPF38A as part of a broader response to differentiation signals. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Another HDAC inhibitor that could potentially increase PRPF38A expression through epigenetic modification of chromatin. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Known to activate signaling pathways that could lead to the transcriptional upregulation of genes including PRPF38A. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Induces DNA damage and could enhance the expression of genes involved in DNA repair and RNA processing. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates cAMP signaling which might impact transcriptional regulation of various genes, including those for splicing factors. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences Wnt signaling and could alter the expression profile of genes including PRPF38A. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Known to induce stress responses that might upregulate RNA processing factors like PRPF38A. | ||||||