PRPF18 Activators
PRPF18, or pre-mRNA processing factor 18, is a crucial component of the human spliceosome, a complex molecular machine responsible for splicing pre-messenger RNA (pre-mRNA). This process is essential for the removal of non-coding sequences (introns) and the joining of coding sequences (exons) to form mature mRNA, which is then translated into proteins. PRPF18 is specifically involved in the catalytic step of splicing, contributing to the precise cleavage and ligation that define exon-intron boundaries.
The function of PRPF18 is highly specialized and integral to the maintenance of genomic integrity. Errors in splicing can lead to a variety of genetic disorders and contribute to the development of diseases such as cancer. The protein is thus a part of a tightly regulated cellular system that responds to various physiological cues to ensure the accurate expression of genetic information.PRPF18's activity is modulated by its interactions with other spliceosomal proteins and RNA molecules, forming a dynamic complex that adapts to the diverse splicing needs of the cell. The expression of PRPF18 itself is likely subject to regulation by cellular factors that monitor and respond to the cell's metabolic state, stress levels, and developmental signals.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
May regulate gene expression through retinoic acid receptors, potentially affecting spliceosome components. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP, which may influence transcription factors and gene expression, including that of PRPF18. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor that can lead to chromatin remodeling and affect gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Inhibits DNA methyltransferases, potentially causing gene demethylation and activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase inhibitor that can affect gene expression by altering chromatin structure. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
May modulate gene expression through epigenetic changes. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoid that can regulate gene expression by acting on glucocorticoid response elements. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
May impact gene expression through pathways such as GSK-3 modulation. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Binds to estrogen receptors, potentially affecting gene transcription in a tissue-specific manner. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C, which can lead to changes in transcription factor activities. | ||||||