PRPF18 Antibody (52): sc-136529
- PRPF18 Antibody (52) is a mouse monoclonal IgG1 κ PRPF18 antibody provided at 200 µg/ml
- raised against amino acids 33-226 of PRPF18 of PRPF18 of human origin
- PRPF18 Antibody (52) is recommended for detection of isoform 1 of PRPF18 of mouse, rat and human origin by WB, IP and IF; non cross-reactive with isoform 2 of PRPF18
- PRPF18 Antibody (52) is available conjugated to agarose for IP; and to HRP for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PRPF18 Antibody (52) for WB applications. This reagent is now offered in a bundle with PRPF18 Antibody (52) (see ordering information below).
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PRPF18 Antibody (52) is a mouse monoclonal IgG1 kappa light chain antibody that detects PRPF18 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). anti-PRPF18 antibody (52) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP) conjugates. PRPF18, also known as pre-mRNA-splicing factor 18 or HPRP18, is a crucial 342 amino acid protein that localizes to nuclear speckles, where PRPF18 plays a vital role in the second step of pre-mRNA splicing. This process is essential for the maturation of precursor mRNA into functional mRNA, which is critical for proper gene expression and cellular function. PRPF18 is a member of the PRP18 family and features seven WD repeats, existing as two alternatively spliced isoforms encoded by a gene located on human chromosome 10p13. PRPF18′s significance extends beyond structural role; PRPF18 is involved in the regulation of gene expression and has implications in various cellular processes, including cell cycle regulation and response to DNA damage. Understanding PRPF18′s function is important, as dysregulation of splicing factors can lead to a range of diseases, including cancer and neurodegenerative disorders.
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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.
Download thiomersal SDS
PRPF18 Antibody (52) References:
- Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21. | Troelstra, C., et al. 1992. Genomics. 12: 745-9. PMID: 1349298
- Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation. | Teresi, RE., et al. 2007. Am J Hum Genet. 81: 756-67. PMID: 17847000
- PTEN: a new guardian of the genome. | Yin, Y. and Shen, WH. 2008. Oncogene. 27: 5443-53. PMID: 18794879
- Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome. | Laugel, V., et al. 2010. Hum Mutat. 31: 113-26. PMID: 19894250
- A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. | Horowitz, DS. and Krainer, AR. 1997. Genes Dev. 11: 139-51. PMID: 9000057
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRPF18 Antibody (52) | sc-136529 | 200 µg/ml | $322.00 | |||
PRPF18 Antibody (52): m-IgG Fc BP-HRP Bundle | sc-551920 | 200 µg Ab; 10 µg BP | $361.00 | |||
PRPF18 Antibody (52) AC | sc-136529 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PRPF18 Antibody (52) HRP | sc-136529 HRP | 200 µg/ml | $322.00 |