PRPF18 Antibody (52): sc-136529

PRPF18 Antibody (52) is a mouse monoclonal IgG1 kappa light chain antibody that detects PRPF18 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). anti-PRPF18 antibody (52) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP) conjugates. PRPF18, also known as pre-mRNA-splicing factor 18 or HPRP18, is a crucial 342 amino acid protein that localizes to nuclear speckles, where PRPF18 plays a vital role in the second step of pre-mRNA splicing. This process is essential for the maturation of precursor mRNA into functional mRNA, which is critical for proper gene expression and cellular function. PRPF18 is a member of the PRP18 family and features seven WD repeats, existing as two alternatively spliced isoforms encoded by a gene located on human chromosome 10p13. PRPF18′s significance extends beyond structural role; PRPF18 is involved in the regulation of gene expression and has implications in various cellular processes, including cell cycle regulation and response to DNA damage. Understanding PRPF18′s function is important, as dysregulation of splicing factors can lead to a range of diseases, including cancer and neurodegenerative disorders.

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PRPF18 Antibody (52) References:

1. Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21.  |  Troelstra, C., et al. 1992. Genomics. 12: 745-9. PMID: 1349298
2. Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation.  |  Teresi, RE., et al. 2007. Am J Hum Genet. 81: 756-67. PMID: 17847000
3. PTEN: a new guardian of the genome.  |  Yin, Y. and Shen, WH. 2008. Oncogene. 27: 5443-53. PMID: 18794879
4. Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome.  |  Laugel, V., et al. 2010. Hum Mutat. 31: 113-26. PMID: 19894250
5. A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor.  |  Horowitz, DS. and Krainer, AR. 1997. Genes Dev. 11: 139-51. PMID: 9000057

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRPF18 Antibody (52) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PRPF18 Antibody (52) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRPF18 Antibody (52) Specifications

Alternate Product Name: PRPF18

Product Clone Name: 52

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 33-226

Epitope Target: PRPF18

Epitope Species: human

Product Reactivity/Detection: isoform 1 of PRPF18

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PRPF18 Antibody (52): AC: Agarose, HRP: Horseradish Peroxidase