PROS-30 Activators
PROS-30, also known as the proteasome subunit alpha type 1, is an integral component of the 20S core of the proteasome complex. This complex plays a pivotal role in the ubiquitin-proteasome pathway, responsible for the degradation of most intracellular proteins. Proper functioning of the proteasome is essential for numerous cellular processes, including the cell cycle, signal transduction, and responses to oxidative stress. The expression of PROS-30 is tightly regulated by the cell due to its critical role in maintaining protein homeostasis and cellular health. Various intracellular signals and environmental stressors can lead to an upsurge in the expression of this proteasome subunit as a part of the cellular strategy to adapt to changes in proteolytic demand.
A range of chemical compounds have been identified that can potentially induce the expression of PROS-30. These activators typically exert their effect by interfering with the proteasome's activity, thereby triggering a compensatory cellular response to restore the balance of protein degradation. For instance, proteasome inhibitors such as MG132 and lactacystin lead to the accumulation of polyubiquitinated proteins, which can signal the need for enhanced proteolytic capacity, prompting the cell to upregulate proteasome subunits such as PROS-30. Additionally, agents that induce cellular stress, such as tunicamycin and thapsigargin, which cause disruptions in protein folding within the endoplasmic reticulum, can also stimulate the expression of PROS-30. This response is part of the unfolded protein response, a well-coordinated reaction to alleviate stress and restore normal cellular function. Through the orchestrated action of these activators, the cell can adapt to proteotoxic challenges by enhancing the expression of crucial components like PROS-30, ensuring efficient degradation and removal of damaged or misfolded proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 acts as a reversible proteasome inhibitor, which can lead to an accumulation of polyubiquitinated proteins. This accumulation often triggers a cellular response that includes the upregulation of proteasome subunits like PROS-30 to enhance the protein degradation capacity of the cell. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib selectively binds to and inhibits the 26S proteasome. In response to this inhibition, cells may increase the synthesis of PROS-30 as a compensatory mechanism to restore normal proteasome function, essential for maintaining cellular proteostasis. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a natural product that irreversibly inhibits proteasomal proteolytic activity. Its action could stimulate a feedback loop that enhances the expression of PROS-30 in an attempt to counterbalance the inhibited proteolysis and maintain cellular homeostasis. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin blocks N-glycosylation in the endoplasmic reticulum (ER), leading to ER stress and the potential activation of the unfolded protein response (UPR). The UPR may then stimulate the expression of PROS-30 to increase the degradation of misfolded proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a potent inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), causing a disturbance in calcium homeostasis and inducing ER stress. The cellular response to this stress may include the upregulation of PROS-30 to alleviate protein aggregation issues. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a naturally occurring, selective inhibitor of the proteasome, known to bind irreversibly to proteasome active sites. In response to such inhibition, cells may upregulate PROS-30 as a means to compensate for the loss of proteolytic function and ensure continued degradation of aberrant proteins. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol, a quinone methide triterpene, has been found to disrupt proteasomal activity. This disruption may prompt cells to induce the expression of PROS-30 to surmount the blockade in the proteolytic pathway and manage protein turnover effectively. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram has been shown to inhibit the proteasome. This inhibition may stimulate a cellular adaptive response that includes the upregulation of PROS-30 to mitigate the effects of impaired proteasome activity and avoid the accumulation of potentially toxic proteins. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic acid is a pentacyclic triterpenoid that has been observed to inhibit the proteasomal degradation of proteins. In response, the cell may induce PROS-30 expression to reinforce the proteolytic machinery and maintain protein homeostasis. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A, found in the medicinal plant Withania somnifera, has been identified as a disruptor of proteasomal activity. Its action may lead to an increase in the expression of PROS-30, as the cell attempts to overcome the reduced proteolytic capacity and prevent the buildup of damaged or misfolded proteins. | ||||||