Properdin Inhibitors
The class of properdin inhibitors would consist of chemical agents that can indirectly downregulate or modulate the activity of the complement system, and by extension, properdin's role within it. Given properdin's function in stabilizing the C3 and C5 convertases, inhibitors within this class might target various stages of the complement cascade from initial activation (C3 convertase formation) to the terminal steps (C5 cleavage and membrane attack complex formation).
These inhibitors act on different proteins of the complement pathway, such as C3, Factor B, Factor D, and C5. Others, like Compstatin, are still under investigation. Their mechanisms of action involve the direct inhibition of key complement components or the blockade of complement receptors, which can indirectly reduce the stabilizing effect of properdin on the convertase complexes. By targeting these various points of intervention, the compounds can modulate the overall activity of the complement cascade, thus affecting the biological context in which properdin operates.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
An alkaloid that may have an inhibitory effect on the complement system, potentially reducing the stabilizing action of properdin. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A polyphenol with anti-inflammatory properties that has been shown to inhibit the complement cascade, thus indirectly affecting properdin. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
A flavonoid that has been reported to inhibit complement activity, which could decrease the functional impact of properdin. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A catechin found in green tea that has been reported to have inhibitory effects on the complement system. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
A mixture of flavonolignans extracted from milk thistle that may exert inhibitory effects on the complement system. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that has shown potential in inhibiting the complement system, which could impact properdin's role. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
An anthraquinone derivative that inhibits the complement system, potentially affecting properdin. | ||||||
Chlorogenic Acid | 327-97-9 | sc-204683 sc-204683A | 500 mg 1 g | $47.00 $69.00 | 1 | |
A polyphenol that may inhibit complement activation and thus indirectly modulate properdin activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A stilbenoid that has been suggested to have inhibitory effects on the complement system. | ||||||
Astragaloside IV | 84687-43-4 | sc-257103 | 20 mg | $57.00 | 1 | |
A saponin found in Astragalus membranaceus with potential inhibitory effects on the complement system. | ||||||