Proliferin-2 Inhibitors
Chemical inhibitors of proliferin-2 operate through various molecular mechanisms to modulate the protein's function. Trichostatin A, a histone deacetylase inhibitor, can enhance histone acetylation, leading to an open chromatin structure that can influence the transcriptional regulation of proliferin-2. This alteration in gene expression can result in reduced production or activity of proliferin-2. Similarly, LY294002 and Wortmannin, both inhibitors of phosphoinositide 3-kinases, can suppress downstream signaling cascades required for the proper functioning of proliferin-2. LY294002's ability to inhibit PI3K can lead to decreased activation of critical signaling pathways, while Wortmannin's irreversible inhibition of PI3K can have a more sustained effect on the signaling necessary for proliferin-2's activity.
In parallel, PD98059 and U0126, both selective inhibitors of MEK, can prevent the activation of the ERK pathway, which is often involved in the regulation of proteins like proliferin-2. PD0325901, another potent MEK inhibitor, operates similarly by blocking ERK activation and consequently reducing proliferin-2 function. Rapamycin, an mTOR inhibitor, can suppress pathways crucial for cell growth and proliferation, potentially affecting the conditions required for optimal activity of proliferin-2. SB203580 and SP600125, which inhibit p38 MAP kinase and c-Jun N-terminal kinase, respectively, can disrupt stress and inflammatory response pathways that can modulate the activity of proliferin-2. ZM-447439, an Aurora kinase inhibitor, can interfere with cellular division processes that may be required for proliferin-2's function. Lastly, Y-27632, a ROCK inhibitor, can alter cell dynamics and SU11274, a Met receptor tyrosine kinase inhibitor, can disrupt proliferin-2 related signaling, leading to functional inhibition of the protein. Each of these inhibitors can contribute to the modulation of proliferin-2 by directly or indirectly disrupting the protein's regulatory networks and signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A (TSA) is a histone deacetylase inhibitor that can increase histone acetylation, leading to a more open chromatin structure and potentially reducing the transcription of proliferin-2 by changing the transcriptional environment of its gene. Inhibition of histone deacetylase activity by TSA leads to the suppression of several genes' expression, which could include those involved in the regulation of proliferin-2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in various signaling pathways, including those that regulate cell growth and survival. Inhibition of PI3K by LY294002 could reduce the activation of downstream effectors that may be necessary for proliferin-2 function, leading to its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is a part of the MAPK/ERK pathway. By inhibiting MEK, PD98059 prevents the activation of ERK, which could be necessary for the signaling that regulates proliferin-2 activity, thereby functionally inhibiting proliferin-2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that can suppress the mTOR pathway, which is crucial for cell growth and proliferation. By inhibiting mTOR, Rapamycin might reduce the cellular conditions necessary for the optimal activity of proliferin-2, leading to its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase, which is involved in response to stress and inflammatory cytokines. Inhibiting p38 kinase by SB203580 could disrupt signaling pathways that regulate the stability or activity of proliferin-2, thus functionally inhibiting it. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K, which is upstream of various cellular processes including cell growth and survival. By inhibiting PI3K, Wortmannin can reduce the activation of downstream pathways that might be necessary for proliferin-2 function, resulting in its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is implicated in a range of cellular processes like apoptosis and cell differentiation. By inhibiting JNK, SP600125 could impair signaling pathways that regulate proliferin-2 activity, leading to its functional inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK, which is part of the MAPK/ERK pathway. Inhibition of MEK by U0126 can prevent ERK activation, potentially reducing the signaling required for proliferin-2 function and thus functionally inhibiting it. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor that can interfere with mitotic progression. As Aurora kinases are involved in cell division, inhibiting them with ZM-447439 could disrupt cellular proliferation, which may be required for the activity of proliferin-2, leading to its functional inhibition. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of the Rho-associated protein kinase (ROCK), which plays a significant role in cell shape, motility, and contraction. By inhibiting ROCK, Y-27632 can alter cellular dynamics that could be crucial for proliferin-2 activity, functionally inhibiting it. | ||||||