pro-MCH Activators
The chemical class of pro-MCH activators encompasses a variety of compounds that modulate pro-MCH expression and function through specific biochemical and cellular pathways. These pathways include the NF-κB, mTOR, SIRT1, PI3K/Akt, MAPK, RhoA/ROCK, AMPK, and Wnt signaling cascades. Curcumin, for instance, indirectly activates pro-MCH by inhibiting NF-κB signaling, a pathway involved in the transcriptional regulation of pro-MCH. Rapamycin, a mTOR inhibitor, indirectly activates pro-MCH by disrupting mTOR-dependent cellular processes that intersect with pro-MCH expression. Similarly, Resveratrol activates pro-MCH by influencing the SIRT1 pathway, which plays a role in cellular processes regulating pro-MCH. The inhibitors LY294002, PD98059, SB203580, Y-27632, CAY10561, SB216763, BAY 11-7082, LY303511, and SB431542 collectively define the pro-MCH activators class by influencing various signaling pathways. LY294002 and LY303511, as PI3K inhibitors, impact pro-MCH through the PI3K/Akt pathway. PD98059 and SB203580, inhibitors of MAPK components, disrupt downstream signaling events that modulate pro-MCH within the context of MAPK pathway regulation.
Y-27632, a ROCK inhibitor, influences pro-MCH by suppressing the RhoA/ROCK pathway, while CAY10561, an AMPK activator, modulates pro-MCH expression through its effects on cellular energy status. SB216763, a GSK-3β inhibitor, indirectly activates pro-MCH by disrupting Wnt pathway regulation, and BAY 11-7082 inhibits NF-κB activation, impacting pro-MCH expression. In summary, the pro-MCH activators class encompasses a diverse range of chemicals, each contributing uniquely to the modulation of pro-MCH within intricate cellular signaling networks. These compounds can serve as valuable tools for understanding the regulatory mechanisms governing pro-MCH expression and may have implications in elucidating the role of pro-MCH in various physiological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural compound from turmeric, modulates pro-MCH by inhibiting the NF-κB signaling pathway. By suppressing NF-κB activation, Curcumin indirectly impacts pro-MCH expression, as NF-κB is involved in the transcriptional regulation of pro-MCH. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key regulator of cell growth and metabolism. Its inhibition of mTOR can indirectly activate pro-MCH, as mTOR is involved in the regulation of pro-MCH expression in certain cellular contexts. The suppression of mTOR by Rapamycin alters cellular signaling, influencing pro-MCH function and expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol influences pro-MCH by activating the Sirtuin-1 (SIRT1) pathway. SIRT1 is involved in cellular processes that intersect with pro-MCH expression. Resveratrol's activation of SIRT1 leads to changes in the cellular environment, influencing pro-MCH expression and function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that indirectly influences pro-MCH by blocking the PI3K/Akt signaling pathway. As the PI3K/Akt pathway is involved in the regulation of pro-MCH expression, the inhibition by LY294002 alters cellular processes, impacting pro-MCH within specific contexts. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK1/2 in the MAPK pathway. By inhibiting MEK1/2, PD98059 indirectly affects pro-MCH activation, as the MAPK pathway plays a role in the regulation of pro-MCH expression. The blockade of MEK1/2 activity disrupts downstream signaling events, influencing cellular processes that modulate pro-MCH within the context of MAPK pathway regulation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. Its inhibition of p38 MAPK indirectly influences pro-MCH activation, as the p38 MAPK pathway is involved in the regulation of pro-MCH expression. The blockade of p38 MAPK alters downstream signaling events, affecting cellular processes that play a role in the regulation of pro-MCH within specific contexts. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that indirectly impacts pro-MCH by suppressing the RhoA/ROCK signaling pathway. As the RhoA/ROCK pathway is involved in the regulation of pro-MCH expression, the inhibition by Y-27632 alters cellular processes, influencing pro-MCH within specific contexts. | ||||||
Pyrazolylpyrrole ERK Inhibitor Inhibitor | 933786-58-4 | sc-222229 sc-222229A | 500 µg 1 mg | $41.00 $78.00 | 3 | |
Pyrazolylpyrrole ERK Inhibitor, CAY10561, is an AMPK activator. Its activation of AMPK indirectly influences pro-MCH by modulating cellular energy status. AMPK, as a key energy sensor, intersects with pathways regulating pro-MCH expression. CAY10561-induced activation of AMPK leads to changes in the cellular environment, impacting pro-MCH function and expression. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB216763 inhibits GSK-3β, a key regulator in the Wnt signaling pathway. The inhibition of GSK-3β indirectly affects pro-MCH activation, as the Wnt pathway plays a role in the regulation of pro-MCH expression. SB216763 alters the cellular context by disrupting Wnt pathway regulation, leading to changes in pro-MCH expression and function within specific cellular contexts. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation, indirectly influencing pro-MCH. As NF-κB is involved in the transcriptional regulation of pro-MCH, the inhibition by BAY 11-7082 alters the cellular environment, impacting pro-MCH expression and function. | ||||||