PRH1 Activators
PRH1 activators are chemical compounds designed to enhance the activity of the proline-rich protein PRH1, a saliva-derived protein that plays a role in the maintenance of oral health. As part of the proline-rich proteins family, PRH1 is involved in various intraoral processes, such as the stabilization of calcium phosphate, which is important for tooth enamel integrity and the prevention of demineralization. Activators of PRH1 function by increasing the protein's biological activity, which may involve promoting its interaction with other salivary components, enhancing its ability to bind calcium, or facilitating its role in the formation of the salivary pellicle. The activation of PRH1 can be achieved through various mechanisms, including conformational changes induced by the activator binding, allosteric modulation, or upregulation of the protein's expression levels within the salivary glands.
The investigation and characterization of PRH1 activators require comprehensive biochemical and molecular analysis to discern their mechanism of action and their interaction with PRH1. This often begins with high-throughput screening of compound libraries to identify molecules that can increase PRH1 activity, followed by detailed studies to understand how these activators engage with the protein at the molecular level. Techniques such as fluorescence spectroscopy, circular dichroism (CD), and mass spectrometry can be utilized to probe the binding and structural effects of activators on PRH1. Additionally, in vitro assays that mimic the conditions of the oral cavity can be used to observe the functional consequences of PRH1 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may upregulate PRH1 by binding to retinoic acid receptors, leading to the transcription of genes involved in cell differentiation and protein production. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound could potentially stimulate PRH1 expression by inhibiting DNA methylation, thereby allowing transcription factors greater access to the DNA. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may increase PRH1 levels by preventing histone deacetylation, which results in a more open chromatin structure and higher transcriptional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin might upregulate PRH1 by enhancing cAMP levels, which activates protein kinase A (PKA) and leads to the activation of transcription factors that stimulate gene expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA could stimulate PRH1 synthesis by activating PKC, which triggers a signaling cascade that leads to the activation of transcription factors and gene expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone might induce PRH1 by interacting with glucocorticoid receptors, which can initiate transcription of anti-inflammatory response genes and possibly PRH1. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol could stimulate the expression of PRH1 by binding estrogen receptors, which then bind to estrogen response elements in gene promoters to activate transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride might increase PRH1 expression through inhibition of GSK-3, thereby stimulating the Wnt signaling pathway and altering gene transcription programs. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $70.00 $281.00 $536.00 $1076.00 $2142.00 | 3 | |
Diethylstilbestrol may induce the expression of PRH1 by mimicking estrogen and binding to estrogen receptors, which then initiates the transcription of estrogen-responsive genes. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $40.00 $75.00 $150.00 | ||
Liothyronine could upregulate PRH1 by binding to thyroid hormone receptors, which can bind DNA and activate gene transcription, including potentially PRH1. | ||||||