Date published: 2025-9-10

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Presenilin 2 Inhibitors

Presenilin 2 inhibitors encompass a diverse array of compounds meticulously designed to modulate the activity of Presenilin 2, a protein intricately involved in the processing of amyloid precursor protein (APP) and linked to neurodegenerative conditions. These inhibitors are crafted through a fusion of molecular insights and mechanistic understanding, often employing advanced techniques like computational modeling, high-throughput screening, and chemical synthesis. The primary goal is to engineer compounds with precision, selectively interacting with Presenilin 2 and potentially influencing its role in proteolytic processing. By targeting Presenilin 2, these inhibitors offer essential tools for unraveling the intricate mechanisms underlying amyloid generation and neuronal dysfunction. The exploration of Presenilin 2 inhibitors contributes to a deeper comprehension of the finely orchestrated processes within cellular signaling, shedding light on the nuanced dynamics that govern protein cleavage and its implications in cellular health.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

LY411575

209984-57-6sc-364529
sc-364529A
10 mg
50 mg
$194.00
$464.00
6
(1)

An experimental compound, LY-411,575 has been studied for its potential inhibitory effects on Presenilin 2-mediated cleavage of APP and its impact on amyloid plaque formation.

DAPT

208255-80-5sc-201315
sc-201315A
sc-201315B
sc-201315C
5 mg
25 mg
100 mg
1 g
$99.00
$335.00
$836.00
$2099.00
47
(3)

This compound has been explored for its interactions with Presenilin 2 and its potential role in modulating the processing of APP.

Compound E

209986-17-4sc-221433
sc-221433A
sc-221433B
250 µg
1 mg
5 mg
$122.00
$335.00
$948.00
12
(2)

Another gamma-secretase inhibitor, Compound E has been investigated for its effects on Presenilin 2-mediated cleavage of APP and its potential implications for neurodegenerative processes.

MK-0752

471905-41-6sc-364534
sc-364534A
10 mg
50 mg
$592.00
$1550.00
(1)

An experimental compound, MK-0752 has been studied for its potential inhibitory effects on Presenilin 2 and its role in amyloid production.

BMS-708163

1146699-66-2sc-364444
sc-364444A
10 mg
50 mg
$480.00
$1455.00
1
(0)

This compound has been explored for its interactions with Presenilin 2 and its potential role in modulating APP processing.

Semagacestat

425386-60-3sc-364614
sc-364614A
10 mg
50 mg
$350.00
$1200.00
1
(0)

This compound has been studied for its potential inhibitory effects on Presenilin 2 and its role in amyloid production.

Aripiprazole

129722-12-9sc-207300
sc-207300A
sc-207300B
100 mg
1 g
5 g
$175.00
$208.00
$1017.00
3
(1)

An antipsychotic agent in research, aripiprazole has been explored for its interactions with Presenilin 2 and its potential implications for neurodegenerative processes.

RO 90-7501

293762-45-5sc-204891
sc-204891A
10 mg
50 mg
$179.00
$759.00
(1)

This compound has been investigated for its effects on Presenilin 2-mediated cleavage of APP and its potential impact on amyloid plaque formation.

Casein Kinase I Inhibitor, D4476

301836-43-1sc-202522
1 mg
$97.00
6
(1)

This compound has been explored for its interactions with Presenilin 2 and its potential role in modulating APP processing.