RO 90-7501 CAS: 293762-45-5
MF: C20H16N6
MW: 340.39
An inhibitor of amyloid β42 fibril assembly.

RO 90-7501 (CAS 293762-45-5)

RO 90-7501 | CAS 293762-45-5 is rated 5.0 out of 5 by 1.
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Alternate Names: 2′-(4-Aminophenyl)-[2,5′-bi-1H-benzimidazol]-5-amine
Application: RO 90-7501 is an inhibitor of amyloid β42 fibril assembly
CAS Number: 293762-45-5
Purity: ≥98%
Molecular Weight: 340.39
Molecular Formula: C20H16N6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

RO 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM).


References

Bohrmann et al (2000) Self-assembly of b-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J.Struct.Biol. 130 232.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and 1eq. HCl (10 mM). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
298.26° C (Predicted)
Boiling Point :
751.04° C at 760 mmHg (Predicted)
Density :
1.44 g/cm3 (Predicted)
Refractive Index :
n20D 1.84 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 0.22 nM
pK Values :
pKa: 10.67 (Predicted), pKb: 6.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
824226
MDL Number :
MFCD00367977
SMILES :
C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C4=NC5=C(N4)C=C(C=C5)N)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Guo et al Guo et al. (PubMed ID 23056170) found that RO 90-7501 potentiated TLR3 and RLR ligand-induced IFN- gene expression and antiviral response, possibly via the selective activation of p38 MAPK pathway. -SCBT Publication Review
Date published: 2015-06-19
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