Molecular structure of Aripiprazole, CAS Number: 129722-12-9
Aripiprazole (CAS 129722-12-9)
See product citations (3)
Alternate Names:
7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
Application:
Aripiprazole is a selective dopamine D2-receptor antagonist showing autoreceptor agonist activity
CAS Number:
129722-12-9
Purity:
≥98%
Molecular Weight:
448.39
Molecular Formula:
C23H27Cl2N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Aripiprazole is an anti-psychotic selective D2DR (dopamine D2-receptor) antagonist with dopamine autoreceptor agonist activity. Aripiprazole is an activator of SR-1A. Aripiprazole works by binding to dopamine and serotonin receptors in the brain. It is a partial agonist at the dopamine D2 receptor and a partial agonist at the serotonin 5-HT1A receptor. This means that it binds to the receptors and activates them, but only partially.
Aripiprazole (CAS 129722-12-9) References
- Aripiprazole: a review of its pharmacology and clinical use. | Taylor, DM. 2003. Int J Clin Pract. 57: 49-54. PMID: 12587943
- Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain. | Li, Z., et al. 2004. Eur J Pharmacol. 493: 75-83. PMID: 15189766
- High performance liquid chromatographic methods for the determination of aripiprazole with ultraviolet detection in rat plasma and brain: application to the pharmacokinetic study. | Shimokawa, Y., et al. 2005. J Chromatogr B Analyt Technol Biomed Life Sci. 821: 8-14. PMID: 15897016
- Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration. | Wee, S., et al. 2007. Neuropsychopharmacology. 32: 2238-47. PMID: 17327886
- Protective effects of lamotrigine, aripiprazole and escitalopram on depression-induced oxidative stress in rat brain. | Eren, I., et al. 2007. Neurochem Res. 32: 1188-95. PMID: 17401662
- Electrophysiological studies in the rat brain on the basis for aripiprazole augmentation of antidepressants in major depressive disorder. | Chernoloz, O., et al. 2009. Psychopharmacology (Berl). 206: 335-44. PMID: 19641901
- Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats. | Skrede, S., et al. 2012. Int J Neuropsychopharmacol. 15: 163-79. PMID: 21854679
- Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidity. | Russo, E., et al. 2013. Neuropharmacology. 64: 371-9. PMID: 22766393
- Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents. | Ye, N., et al. 2014. Curr Med Chem. 21: 437-57. PMID: 24164194
- Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: a longitudinal 1H-NMR spectroscopy study at 11.7T. | Rizzo, F., et al. 2017. Transl Psychiatry. 7: e1189. PMID: 28763063
- Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions. | Johnston, AN., et al. 2018. Breast Cancer Res. 20: 42. PMID: 29778097
- Antipsychotic- and Anxiolytic-like Properties of a Multimodal Compound JJGW08 in Rodents. | Żmudzka, E., et al. 2022. Int J Mol Sci. 23: PMID: 36555568
Inhibitor of:
D2, D2DR, DGCR2, Dopamine, Mtvr2, Olfr1, Olfr1032, Olfr1056, Olfr251, Olfr427, Olfr509, Olfr826, Olfr884, Olfr95, Olr235, Olr401, OR5K1, Prolactin, SEZ6, TAAR7B, V1RB7, and V1RB8.Activator of:
D2DR, GLOD5, and SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aripiprazole, 100 mg | sc-207300 | 100 mg | $175.00 | |||
Aripiprazole, 1 g | sc-207300A | 1 g | $208.00 | |||
Aripiprazole, 5 g | sc-207300B | 5 g | $1017.00 |