Molecular structure of Semagacestat, CAS Number: 425386-60-3
Semagacestat (CAS 425386-60-3)
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Alternate Names:
LY450139
Application:
Semagacestat is magacestat is a γ-secretase blocker of Aβ42, Aβ40 and Aβ38
CAS Number:
425386-60-3
Purity:
≥97%
Molecular Weight:
361.44
Molecular Formula:
C19H27N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Semagacestat causes a reduction in the secretion of Aβ42, Aβ40 and Aβ38 from H4 human glioma cells stably overexpressing human wild-type APP into the culture medium. Semagacestat increases β-CTF in cell lysates, and the increase can be attenuated at high concentrations. Semagacestat inhibits Notch signaling with IC50 of 14.1 nM, and shows minimal Notch-sparing selectivity with Notch IC50/Aβ42 IC50 only 1.3. Semagacestat causes a concentration-dependent decrease in Aβ40 secreted into the medium with IC50 of 111 nM from murine CTX expressing endogenous murine APP, but murine Aβ42 formation in CTX is roughly 12-fold less than Aβ40 in accordance with data for neurons from wild type mice.
Inhibitor of:
AGPS, Aph-1, Aph-1c, APLP1, Deltex (DTX; E3 ubiquitin ligase), fringe, Gamma-secretase, HES4, HES7, ITM2A, Jagged, KIAA1024L_A730017C20Rik, kismet-L, Manic Fringe, Notch, Nrarp, NUMB, Pecanex 1, PION, pS2, PSAP, SEL-12, SPPL3, TLE5, and X11α.Activator of:
Aph-1b, Aph-1c, Notch 2, and SPPL3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Semagacestat, 10 mg | sc-364614 | 10 mg | $350.00 | |||
Semagacestat, 50 mg | sc-364614A | 50 mg | $1200.00 |