Semagacestat CAS: 425386-60-3
MF: C19H27N3O4
MW: 361.44
A γ-secretase blocker of Aβ42, Aβ40 and Aβ38.

Semagacestat (CAS 425386-60-3)

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Synonym: LY450139
Application: A γ-secretase blocker of Aβ42, Aβ40 and Aβ38
CAS Number: 425386-60-3
Purity: ≥97%
Molecular Weight: 361.44
Molecular Formula: C19H27N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).

Semagacestat is an inhibitor of the γ-secretase complex. It causes a reduction in the secretion of Aβ42, Aβ40 and Aβ38 from H4 human glioma cells stably overexpressing human wild-type APP into the culture medium. Semagacestat increases β-CTF in cell lysates, and the increase can be attenuated at high concentrations. Semagacestat inhibits Notch signaling with IC50 of 14.1 nM, and shows minimal Notch-sparing selectivity with Notch IC50/Aβ42 IC50 only 1.3. Semagacestat causes a concentration-dependent decrease in Aβ40 secreted into the medium with IC50 of 111 nM from murine CTX expressing endogenous murine APP, but murine Aβ42 formation in CTX is roughly 12-fold less than Aβ40 in accordance with data for neurons from wild type mice.

Physical State :
Solid
Solubility :
Soluble in DMSO (72 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (41 mg/ml at 25 °C), and 0.5 methylcellulose (30 mg/ml at 25 °C).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9843750
MDL Number :
MFCD09970409
SMILES :
C[[email protected]@H](C(=O)N[[email protected]]1C2=CC=CC=C2CCN(C1=O)C)NC(=O)[[email protected]](C(C)C)O

Download SDS (MSDS)

Certificate of Analysis

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