PRDM5 Activators
PRDM5, which stands for PR/SET Domain 5, is a protein encoded by the PRDM5 gene in humans. It's a member of the PRDM family of proteins, which are characterized by the presence of a PR/SET domain, a region that can modify chromatin by adding methyl groups to histone proteins.PRDM5 is a transcription factor, meaning it can bind to specific sequences of DNA to regulate the transcription of genetic information from DNA to mRNA. It's known to regulate genes involved in extracellular matrix formation and bone development, among other processes.
Interestingly, PRDM5 has been linked to several types of human disorders. Mutations in the PRDM5 gene have been associated with brittle cornea syndrome, a genetic disorder characterized by thin, fragile corneas and other connective tissue problems. This association underscores PRDM5's role in extracellular matrix formation and maintenance.Moreover, PRDM5 has been implicated in cancer. It's often silenced in a variety of cancers, including breast, colorectal, and lung cancers, and is considered a tumor suppressor. Its silencing is frequently due to genetic and epigenetic changes, leading to alterations in cell growth, differentiation, and apoptosis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor, potentially impacting PRDM5's role in transcriptional repression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor, could indirectly influence PRDM5 activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor, potentially affecting PRDM5 function. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor, could indirectly modulate PRDM5's transcriptional regulation. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
An inhibitor of G9a histone methyltransferase, potentially impacting PRDM5 activity. | ||||||
Pyridostatin | 1085412-37-8 | sc-476422 | 10 mg | $350.00 | ||
A Jumonji C-domain-containing histone demethylase inhibitor, potentially affecting PRDM5. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Known to inhibit Jumonji C-domain-containing demethylases, could affect PRDM5 indirectly. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Affects NF-kB signaling, which might intersect with PRDM5-mediated transcriptional regulation. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
A MDM2 inhibitor, potentially influencing p53 pathways that could intersect with PRDM5's function. | ||||||