Pyridostatin (CAS 1085412-37-8)

Pyridostatin is a synthetic small molecule that uniquely targets and stabilizes G-quadruplexes (G4s), complex nucleic acid structures formed by guanine-rich sequences of DNA and RNA. These G-quadruplexes are prevalent in the regulatory regions of genes and telomeres, playing critical roles in DNA replication, transcription, and genomic stability. By binding to these G4 structures, Pyridostatin disrupts the normal function of these regulatory elements, leading to a halt in the replication and transcription processes that are essential for cell division and growth. This mechanism of action positions Pyridostatin as a powerful tool in molecular biology and genetics research, enabling scientists to explore the functional implications of G-quadruplex stabilization in genomic regulation and stability. Its ability to selectively interact with these complex structures without affecting other DNA or RNA forms makes it invaluable for studies focused on understanding the molecular underpinnings of genomic regulation and the potential role of G-quadruplexes in genetic diseases and aging.