PRAMEF1 Activators
PRAMEF1, part of the PRAME (Preferentially Expressed Antigen in Melanoma) family of genes, has garnered significant interest within the research community for its involvement in gene expression regulation and its possible role in the inhibition of retinoic acid signaling. PRAMEF1 is a member of a family of cancer-testis antigens known to be expressed in a variety of human cancers and is implicated in processes that include evading immune response and modulating cell differentiation. The expression of PRAMEF1, like many genes, is subject to complex regulation by a variety of intracellular and extracellular signals. Understanding the factors that can induce the expression of PRAMEF1 is crucial for elucidating its function and role in cellular physiology.
Research has identified a number of chemical compounds that can potentially serve as activators of PRAMEF1 expression. These chemicals exert their effects through diverse mechanisms, altering the cellular landscape at the molecular level to stimulate the transcription of PRAMEF1. For instance, compounds such as 5-Aza-2'-deoxycytidine may reverse hypermethylation of gene promoters, potentially leading to the reactivation of genes like PRAMEF1. HDAC inhibitors, including Vorinostat and Trichostatin A, increase the acetylation of histones, which can result in a more open chromatin structure conducive to gene transcription. Retinoic acid, a well-known agent in cell differentiation, may trigger transcriptional cascades that elevate PRAMEF1 levels. Disulfiram and Sulforaphane could induce stress responses that lead to the upregulation of certain genes, potentially including PRAMEF1. Genistein and DIM (Diindolylmethane) alter cell-signaling pathways, which may result in the stimulation of PRAMEF1 transcription. Each of these compounds engages with specific cellular pathways, resulting in the elevation of PRAMEF1 transcript levels, highlighting the complexity of gene regulation and the diverse mechanisms through which gene expression can be modulated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound acts as a DNA methyltransferase inhibitor, potentially reversing the hypermethylation of gene promoter regions, thereby reactivating the transcription of genes such as PRAMEF1. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid, an HDAC inhibitor, may promote the acetylation of histones, leading to a more open chromatin structure and possibly stimulating the transcriptional activation of PRAMEF1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylase, Trichostatin A could enhance histone acetylation, creating a transcriptionally permissive state that may upregulate PRAMEF1 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, through its role as an activator of retinoic acid receptors, may initiate transcriptional cascades that upregulate genes involved in cell differentiation, including potentially PRAMEF1. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram may increase the accumulation of ubiquitinated proteins, potentially leading to stress responses that stimulate the transcription of certain genes, possibly including PRAMEF1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, by inhibiting specific tyrosine kinases, may alter signaling pathways, leading to the upregulation of genes that control cell growth and differentiation, such as PRAMEF1. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid, through its HDAC inhibitory activity, may promote an open chromatin state and induce the transcription of genes involved in cell cycle regulation, potentially including PRAMEF1. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, as an HDAC inhibitor, could trigger an increase in histone acetylation levels, possibly resulting in the transcriptional upregulation of PRAMEF1. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid can activate transcription factors that govern cell survival and apoptosis, potentially leading to the induction of genes like PRAMEF1 as part of cellular defense mechanisms. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may stimulate the expression of detoxification enzymes and other protective genes by activating the Nrf2 signaling pathway, which could include the upregulation of PRAMEF1 expression. | ||||||