PR48 Activators
PR48 Activators encompass a diverse array of chemical compounds that influence PR48's activity through various intracellular signaling mechanisms. Forskolin, by raising intracellular cAMP levels, indirectly boosts PR48's function through the activation of PKA, which may phosphorylate PR48 or related proteins. PMA, acting as a DAG analog, stimulates PKC, which could lead to the phosphorylation of PR48, thereby enhancing its activity in signaling pathways where PKC is a crucial player. EGCG, through its inhibitory effect on certain protein kinases, might alleviate negative regulation on PR48, allowing for its increased activity. Sildenafil and Tadalafil, both PDE5 inhibitors, elevate cGMP concentrations within cells, potentially facilitating PKG-mediated phosphorylation of PR48 or modification of its activity via cGMP-dependent pathways. Additionally, S1P activates its receptors leading to MAPK pathway modulation, which could indirectly enhance PR48 activity, while LY294002's inhibition of PI3K may augment PR48 function by attenuating negative feedback loops.
Further, A23187's elevation of intracellular calcium levels might activate CaMKs that directly or indirectly increase PR48's activity. Zoledronic acid disrupts protein prenylation, potentially enhancing PR48's activity by modifying its membrane association or interaction with other membrane proteins. The action of 5-Azacytidine, although not a direct activator, might lead to increased PR48 activity through the altered expression of regulatory proteins within its signaling pathways. Retinoic acid's modulation of gene expression through RARs could result in an upregulation of proteins that positively influence PR48's function. Lastly, Trichostatin A, by inhibiting histone deacetylases, may upregulate proteins that facilitate PR48's activity. Each of these compounds, through their targeted influence on cellular signaling, contributes to the enhancement of PR48's functionality without the need for direct activation or upregulation of its expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which in turn can phosphorylate PR48, enhancing its functional activity within its specific cellular context. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that activates protein kinase C (PKC). PKC can phosphorylate PR48 or associated regulatory proteins, which may result in enhanced activity of PR48 in signaling pathways where PKC plays a role. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that can act as an antioxidant and has been shown to inhibit certain protein kinases. This inhibition can result in the alteration of kinase-dependent signaling pathways, which could lead to enhanced activity of PR48 through reduced negative regulation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that activates S1P receptors and subsequently can activate multiple signaling pathways, such as those involving MAPK. Activation of these pathways might enhance the activity of PR48 by post-translational modifications or by altering the cellular microenvironment. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter the PI3K/AKT pathway. By inhibiting PI3K, LY294002 can modulate downstream signaling, which could lead to an indirect enhancement of PR48 activity by reducing negative feedback mechanisms. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, activating calmodulin-dependent kinases (CaMKs). These kinases might directly phosphorylate PR48 or modify its regulators, enhancing PR48's activity. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $90.00 $251.00 | 5 | |
Zoledronic acid is a bisphosphonate that inhibits farnesyl pyrophosphate synthase in the mevalonate pathway, which could lead to alterations in protein prenylation and membrane localization, potentially enhancing PR48 activity by changing its localization or interaction with other membrane-associated proteins. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, which can lead to the hypomethylation of DNA and alter gene expression patterns. While not directly enhancing PR48's activity, it may indirectly increase PR48's functional activity by affecting the expression of regulatory proteins within PR48's pathway. | ||||||
Tadalafil | 171596-29-5 | sc-208412 | 50 mg | $176.00 | 13 | |
Tadalafil, similar to Sildenafil, inhibits PDE5 leading to an increase in cGMP levels, and potentially enhancing PR48 activity through cGMP-dependent protein kinase (PKG) signaling pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, the active metabolite of vitamin A, regulates gene expression through retinoic acid receptors (RARs). This regulation can lead to changes in protein expression profiles, potentially enhancing PR48 activity by upregulating proteins that positively regulate PR48 function. | ||||||