PPM1H Activators
PPM1H Activators are a select group of compounds that indirectly promote the functional activity of PPM1H, a serine/threonine phosphatase, by influencing the cellular phosphoprotein landscape. The accumulation of phosphorylated proteins, due to the action of Okadaic Acid and Calyculin A as inhibitors of PP1 and PP2A, creates an increased demand for PPM1H phosphatase activity. Similarly, compounds like Forskolin, Ionomycin, and Phorbol 12-myristate 13-acetate (PMA) activate signaling pathways that enhance protein phosphorylation, indirectly necessitating the dephosphorylation role of PPM1H. Forskolin, by increasing cAMP, and PMA, as a PKC activator, both contribute to an environment rich in phosphorylated proteins, which PPM1H then counteracts to maintain cellular function. Ionomycin's elevation of calcium levels can activate a plethora of kinases, thus indirectly enhancing PPM1H activity due to the resulting rise in phosphorylated proteins requiring dephosphorylation for cellular signaling reset.
Further on, the inhibition of protein phosphatases by Cantharidin, Endothall, and Tautomycin leads to a similar indirect upregulation of PPM1H activity as the cell compensates for the inhibited dephosphorylation pathway. Zoledronic Acid disrupts protein prenylation, potentially impacting signaling processes where PPM1H-mediated dephosphorylation is necessary. Anisomycin, through the activation of stress kinases, and Caffeine, by elevating cAMP levels, both contribute to a phosphorylation cascade that could amplify the demand for PPM1H's regulatory role. Lastly, Bisindolylmaleimide I, by inhibiting PKC, might create a unique phosphorylation pattern that requires PPM1H's activity to restore protein phosphorylation homeostasis. Collectively, these chemicals form a network of indirect activators that enhance PPM1H's role in cellular signaling by manipulating the balance of phosphorylation and dephosphorylation within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A, which indirectly can lead to the functional activation of PPM1H by increasing the cellular demand for dephosphorylation activity due to the accumulation of phosphorylated proteins. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A, similar to Okadaic Acid, inhibits PP1 and PP2A, thus potentially enhancing the activity of PPM1H by creating a relative need for its phosphatase activity in the cell. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels and activating PKA. PKA can phosphorylate various proteins, which may require subsequent dephosphorylation by PPM1H to reset the signaling pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially activating calcium-dependent protein kinases and phosphatases. Elevated kinase activity could increase protein phosphorylation, necessitating enhanced PPM1H activity for homeostasis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC) which phosphorylates serine and threonine residues on various proteins, potentially increasing the substrate availability for PPM1H. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Cantharidin inhibits serine/threonine protein phosphatases, which could cause an increase in phosphorylated substrates within the cell, potentially enhancing the role of PPM1H in counterbalancing this effect. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $48.00 $199.00 | 1 | |
Endothall acts as an inhibitor of PP2A and PP1, which could indirectly increase the functional activity of PPM1H by preventing dephosphorylation of its potential substrates by these phosphatases. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $90.00 $251.00 | 5 | |
Zoledronic Acid inhibits farnesyl pyrophosphate synthase, leading to disruption of protein prenylation, which might affect signaling pathways where PPM1H is involved in dephosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases, potentially increasing phosphorylated protein substrates for PPM1H. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tautomycin is another inhibitor of PP1 and PP2A, which might indirectly increase PPM1H activity due to a higher amount of phosphorylated proteins. | ||||||