Ppil3 Activators
SEE ALSO...
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA, which can phosphorylate target proteins, including Ppil3, leading to its functional activation through conformational changes that enhance its peptidyl-prolyl isomerase activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC) which can subsequently phosphorylate and activate downstream proteins. PKC-mediated phosphorylation of components within Ppil3's pathway can lead to the functional activation of Ppil3. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore, increasing intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase (CaMK), which could then phosphorylate Ppil3 or associated regulatory proteins, resulting in the functional activation of Ppil3. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. Inhibition of these phosphatases can lead to increased phosphorylation levels of proteins, including Ppil3, due to reduced dephosphorylation, thereby promoting Ppil3's functional activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Similar to okadaic acid, Calyculin A inhibits protein phosphatases 1 and 2A, which can lead to hyperphosphorylation of cellular proteins. This can result in the enhancement of Ppil3's activity due to reduced dephosphorylation of proteins that participate in Ppil3's functional pathway. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a pyrrolidine antibiotic that activates stress-activated protein kinases (SAPKs) like JNK. Activation of these kinases can lead to the phosphorylation and subsequent activation of Ppil3 as part of the cellular stress response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels. The resulting activation of Ca2+/calmodulin-dependent processes may lead to the activation of Ppil3 through phosphorylation by Ca2+ sensitive kinases. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can act as allosteric modulators of many enzymes. Zinc binding to specific sites on Ppil3 can induce a conformational change that results in its functional activation. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine can induce autophagy through the activation of AMPK. The autophagic process involves numerous regulatory proteins that may include Ppil3, leading to its activation through conformational changes or by enabling its interaction with other proteins. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable analog of cAMP. It activates PKA, leading to phosphorylation of target proteins. PKA may phosphorylate Ppil3 or associated regulatory proteins, resulting in the functional activation of Ppil3. | ||||||