PPAR gamma Activators
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Items 31 to 40 of 51 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rosiglitazone Maleate | 155141-29-0 | sc-280069 | 20 mg | $163.00 | 1 | |
Rosiglitazone Maleate acts as a selective PPAR gamma agonist, characterized by its unique hydrophobic interactions with the receptor's ligand-binding pocket. This compound enhances receptor dimerization with RXR, facilitating the transcription of target genes involved in glucose and lipid metabolism. Its binding kinetics reveal a slow off-rate, contributing to sustained receptor engagement and prolonged biological effects. Additionally, it exhibits distinct conformational changes that optimize its interaction with coactivators, influencing metabolic pathways. | ||||||
Rosiglitazone-d3 Maleate | 155141-29-0 | sc-224260 sc-224260A | 1 mg 5 mg | $140.00 $548.00 | ||
Rosiglitazone-d3 Maleate functions as a selective PPAR gamma modulator, distinguished by its isotopic labeling that allows for precise tracking in metabolic studies. Its unique binding affinity promotes specific conformational shifts within the receptor, enhancing the recruitment of transcriptional co-regulators. The compound's interaction dynamics reveal a notable stability in the ligand-receptor complex, which may influence downstream signaling pathways and metabolic regulation. | ||||||
GW 1929 | 196808-24-9 | sc-202640 | 1 mg | $89.00 | ||
A synthetic PPARγ agonist that binds to the receptor, stimulating the transcription of genes involved in adipogenesis and lipid storage. | ||||||
GW1929 | 1049740-86-4 | sc-300778 | 5 mg | $160.00 | ||
GW1929 acts as a selective PPAR gamma agonist, characterized by its ability to induce specific receptor conformations that facilitate gene expression modulation. Its unique structural features enable strong interactions with the ligand-binding domain, promoting enhanced receptor dimerization. The compound exhibits distinct kinetic profiles, influencing the rate of receptor activation and subsequent transcriptional responses, thereby impacting metabolic pathways in a nuanced manner. | ||||||
S26948 | 353280-43-0 | sc-361331 sc-361331A | 10 mg 50 mg | $214.00 $880.00 | ||
S26948 functions as a selective PPAR gamma modulator, distinguished by its capacity to stabilize receptor-ligand interactions through unique hydrogen bonding and hydrophobic contacts. This compound exhibits a remarkable ability to alter receptor dynamics, enhancing the affinity for coactivators and influencing downstream signaling pathways. Its kinetic behavior reveals a rapid onset of action, allowing for precise regulation of gene transcription related to lipid metabolism and insulin sensitivity. | ||||||
9-Nitrooleate | 875685-44-2 | sc-204632 sc-204632A sc-204632B sc-204632C | 50 µg 100 µg 1 mg 10 mg | $57.00 $88.00 $610.00 $6024.00 | ||
9-Nitrooleate acts as a selective PPAR gamma modulator, characterized by its unique ability to induce conformational changes in the receptor. This compound engages in specific electrostatic interactions that enhance receptor activation, promoting a distinct recruitment of transcriptional co-regulators. Its influence on gene expression is marked by a nuanced modulation of metabolic pathways, showcasing a dynamic interplay between ligand binding and receptor functionality. | ||||||
CAY10599 | 1143573-33-4 | sc-223876 sc-223876A | 1 mg 5 mg | $92.00 $415.00 | ||
CAY10599 serves as a selective PPAR gamma agonist, distinguished by its capacity to stabilize the receptor's active conformation. This compound exhibits unique hydrophobic interactions that facilitate the recruitment of specific co-activators, thereby influencing downstream signaling pathways. Its kinetic profile reveals a rapid association and dissociation with the receptor, allowing for fine-tuned regulation of metabolic gene expression and cellular responses. | ||||||
10-Nitrooleate | 88127-53-1 | sc-204608 sc-204608A | 50 µg 100 µg | $30.00 $43.00 | ||
10-Nitrooleate functions as a PPAR gamma modulator, characterized by its ability to induce conformational changes in the receptor. This compound engages in specific hydrogen bonding and hydrophobic interactions, enhancing the receptor's affinity for co-regulators. Its unique reaction kinetics enable a swift transition between active and inactive states, promoting nuanced control over gene transcription related to lipid metabolism and inflammation. | ||||||
rosiglitazone hydrochloride | 302543-62-0 | sc-280068 | 5 mg | $340.00 | ||
Rosiglitazone hydrochloride acts as a PPAR gamma modulator, exhibiting a distinctive ability to stabilize the receptor's active conformation through specific ligand-receptor interactions. Its unique binding profile facilitates the recruitment of transcriptional co-activators, influencing downstream signaling pathways. The compound's selective affinity for PPAR gamma allows for precise modulation of gene expression, impacting metabolic processes and cellular differentiation. Its dynamic interaction with the receptor underscores its role in fine-tuning metabolic regulation. | ||||||
Rosiglitazone-d3 | sc-219992 | 1 mg | $330.00 | |||
Rosiglitazone-d3 functions as a PPAR gamma agonist, characterized by its isotopic labeling that enhances tracking in metabolic studies. This compound exhibits a unique binding affinity, promoting conformational changes in the receptor that facilitate the recruitment of specific co-regulators. Its distinct kinetic profile allows for nuanced modulation of transcriptional activity, influencing various metabolic pathways. The isotopic nature of Rosiglitazone-d3 aids in elucidating molecular interactions and dynamics within cellular environments. | ||||||