Molecular structure of GW1929, CAS Number: 196808-24-9
GW1929 (CAS 1049740-86-4)
Alternate Names:
N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine
Application:
GW1929 is a high-affinity agonist of PPARγ
CAS Number:
1049740-86-4
Purity:
≥98%
Molecular Weight:
495.57 (anhydrous basis)
Molecular Formula:
C30H29N3O4· xH2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GW1929 is a high affinity agonist of PPAR-γ.
GW1929 (CAS 1049740-86-4) References
- A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. | Brown, KK., et al. 1999. Diabetes. 48: 1415-24. PMID: 10389847
- Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones. | Kim, JH., et al. 2001. J Biol Chem. 276: 24667-73. PMID: 11319222
- Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. | Way, JM., et al. 2001. J Biol Chem. 276: 25651-3. PMID: 11373275
- Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells. | Sung, CK., et al. 2004. Am J Physiol Gastrointest Liver Physiol. 286: G722-9. PMID: 14656714
- Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. | Heppner, TJ., et al. 2005. Pharmacology. 73: 15-22. PMID: 15452359
- Effects of the PPARgamma agonist GW1929 on muscle wasting in tumour-bearing mice. | Moore-Carrasco, R., et al. 2008. Oncol Rep. 19: 253-6. PMID: 18097603
- Role of G protein-coupled receptor kinase-2 in peroxisome proliferator-activated receptor gamma-mediated modulation of blood pressure and renal vascular reactivity in SHR. | Yousefipour, Z., et al. 2009. Am J Nephrol. 30: 201-8. PMID: 19420904
- Ameliorative effects of GW1929, a nonthiazolidinedione PPARγ agonist, on inflammation and apoptosis in focal cerebral ischemic-reperfusion injury. | Kaundal, RK. and Sharma, SS. 2011. Curr Neurovasc Res. 8: 236-45. PMID: 21722092
- Sildenafil inhibits hypoxia-induced transient receptor potential canonical protein expression in pulmonary arterial smooth muscle via cGMP-PKG-PPARγ axis. | Wang, J., et al. 2013. Am J Respir Cell Mol Biol. 49: 231-40. PMID: 23526219
- Epidermal fatty acid-binding protein protects nerve growth factor-differentiated PC12 cells from lipotoxic injury. | Liu, JW., et al. 2015. J Neurochem. 132: 85-98. PMID: 25147052
- Peroxisome Proliferator-Activated Receptor γ-Mediated Inhibition on Hypoxia-Triggered Store-Operated Calcium Entry. A Caveolin-1-Dependent Mechanism. | Yang, K., et al. 2015. Am J Respir Cell Mol Biol. 53: 882-92. PMID: 26020612
- Telmisartan ameliorates adipoR1 and adipoR2 expression via PPAR-γ activation in the coronary artery and VSMCs. | Shen, X., et al. 2017. Biomed Pharmacother. 95: 129-136. PMID: 28837879
- Characterization of the metabolites of GW1929 in rat by liquid chromatography coupled with electrospray ionization tandem mass spectrometry. | Qin, Y., et al. 2020. Rapid Commun Mass Spectrom. 34: e8585. PMID: 31515879
- Effects of GW1929 on uterus, ovary and bone metabolism function in perimenopause rats. | Wang, X., et al. 2020. Am J Transl Res. 12: 1884-1893. PMID: 32509184
- Shentong Zhuyu Decoction Inhibits Inflammatory Response, Migration, and Invasion and Promotes Apoptosis of Rheumatoid Arthritis Fibroblast-like Synoviocytes via the MAPK p38/PPARγ/CTGF Pathway. | Han, Y., et al. 2021. Biomed Res Int. 2021: 6187695. PMID: 33511203
Inhibitor of:
Angiogenesis, and Apoptosis.Activator of:
PPAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW1929, 5 mg | sc-300778 | 5 mg | $160.00 |