Molecular structure of CAY10599, CAS Number: 1143573-33-4
CAY10599 (CAS 1143573-33-4)
Alternate Names:
2-[[1-[3-[4-([1,1′-biphenyl]-4-ylcarbonyl)-2-propylphenoxy]propyl]-1,2,3,4-tetrahydro-5-quinolinyl]oxy]-2-methyl-propanoic acid
Application:
CAY10599 is a TZD that is a PPARγ agonist
CAS Number:
1143573-33-4
Purity:
≥98%
Molecular Weight:
591.75
Molecular Formula:
C38H41NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo (1,2). The prototypical compound for this class is the TZD rosiglitazone (BRL 49653), which is currently marketed for diabetes treatment. CAY10599 is a PPARγ agonist that is 4-fold more potent than rosiglitazone at PPARγ demonstrating an EC50 value of 0.05 µM (3). This compound shows high selectivity for the PPARγ receptor over PPARδ (EC50 > 10 µM) or PPARα (EC50 = 3.99 µM) (3).
CAY10599 (CAS 1143573-33-4) References
- Pioglitazone acutely reduces energy metabolism and insulin secretion in rats. | Lamontagne, J., et al. 2013. Diabetes. 62: 2122-9. PMID: 23378607
- Cyclic Stretch Facilitates Myogenesis in C2C12 Myoblasts and Rescues Thiazolidinedione-Inhibited Myotube Formation. | Chang, YJ., et al. 2016. Front Bioeng Biotechnol. 4: 27. PMID: 27047938
- Development and screening of byproduct for its secondary metabolites, antioxidant and anti-diabetic potential from anthracnose-infected fruits of pomegranate: a sustainable approach. | Jain, K., et al. 2021. 3 Biotech. 11: 74. PMID: 33505829
Activator of:
PPAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAY10599, 1 mg | sc-223876 | 1 mg | $92.00 | |||
CAY10599, 5 mg | sc-223876A | 5 mg | $415.00 |