Molecular structure of S26948, CAS Number: 353280-43-0
S26948 (CAS 353280-43-0)
Alternate Names:
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioic acid dimethyl ester
Application:
S26948 is a selective PPARγ agonist
CAS Number:
353280-43-0
Molecular Weight:
519.57
Molecular Formula:
C28H25NO7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
S26948 has been shown to be a selective PPARγ agonist. This compound also displays the ability to cause normal adipocyte differentiation and decrease lipid levels in murine models.
S26948 (CAS 353280-43-0) References
- S26948, a new specific peroxisome proliferator activated receptor gamma modulator improved in vivo hepatic insulin sensitivity in 48 h lipid infused rats. | Sohn, KA., et al. 2009. Eur J Pharmacol. 608: 104-11. PMID: 19250932
- Selective peroxisome proliferator-activated receptor-γ modulation to reduce cardiovascular risk in patients with insulin resistance. | Yew, T., et al. 2012. Recent Pat Cardiovasc Drug Discov. 7: 33-41. PMID: 22044303
- PPAR agonists for the treatment of cardiovascular disease in patients with diabetes. | Wilding, JP. 2012. Diabetes Obes Metab. 14: 973-82. PMID: 22443197
- Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications--a review. | Grygiel-Górniak, B. 2014. Nutr J. 13: 17. PMID: 24524207
- The role of PPARγ-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology. | Ramot, Y., et al. 2015. Exp Dermatol. 24: 245-51. PMID: 25644500
- A Brief Discussion on Lipid Activated Nuclear Receptors and their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD). | Choudhary, M. and Malek, G. 2016. Adv Exp Med Biol. 854: 45-51. PMID: 26427392
- Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis. | Liu, HJ., et al. 2016. PPAR Res. 2016: 2198645. PMID: 27293418
- Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications. | Mirza, AZ., et al. 2019. Eur J Med Chem. 166: 502-513. PMID: 30739829
- Altered lipid homeostasis in a PCB-resistant Atlantic killifish (Fundulus heteroclitus) population from New Bedford Harbor, MA, U.S.A. | Crawford, KA., et al. 2019. Aquat Toxicol. 210: 30-43. PMID: 30822701
- Tributyltin disrupts fin development in Fundulus heteroclitus from both PCB-sensitive and resistant populations: Investigations of potential interactions between AHR and PPARγ. | Crawford, KA., et al. 2020. Aquat Toxicol. 218: 105334. PMID: 31743820
- A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite Adipogens. | Kim, S., et al. 2021. Environ Health Perspect. 129: 77006. PMID: 34323617
- An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor. | Anagnostopoulos, G., et al. 2022. Cell Death Dis. 13: 356. PMID: 35436993
Activator of:
PPAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S26948, 10 mg | sc-361331 | 10 mg | $214.00 | |||
| US: Only available in the US | ||||||
S26948, 50 mg | sc-361331A | 50 mg | $880.00 | |||
| US: Only available in the US | ||||||