Molecular structure of GW 1929, CAS Number: 196808-24-9
GW 1929 (CAS 196808-24-9)
Application:
GW 1929 is a potent, tyrosine-based PPARγ
CAS Number:
196808-24-9
Purity:
>97%
Molecular Weight:
495.6
Molecular Formula:
C30H29N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GW 1929 is a potent, tyrosine-based peroxisome proliferator-activated receptor g (PPARg) agonist (EC50 = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays).
GW 1929 (CAS 196808-24-9) References
- A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. | Brown, KK., et al. 1999. Diabetes. 48: 1415-24. PMID: 10389847
- The PPARs: from orphan receptors to drug discovery. | Willson, TM., et al. 2000. J Med Chem. 43: 527-50. PMID: 10691680
- Peroxisome proliferator-activated receptor alpha and gamma agonists upregulate human macrophage lipoprotein lipase expression. | Li, L., et al. 2002. Atherosclerosis. 165: 101-10. PMID: 12208475
- Up-regulation of p21 gene expression by peroxisome proliferator-activated receptor gamma in human lung carcinoma cells. | Han, S., et al. 2004. Clin Cancer Res. 10: 1911-9. PMID: 15041706
- Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. | Heppner, TJ., et al. 2005. Pharmacology. 73: 15-22. PMID: 15452359
- IBC's 6th International Symposium on Obesity and 3rd International Symposium on Insulin Resistance: March 22-25, 1999, Washington, DC. | Lenhard, JM. and Cobb, JE. 1999. Expert Opin Investig Drugs. 8: 911-6. PMID: 15992140
- Gestational and hormonal regulation of human placental lipoprotein lipase. | Magnusson-Olsson, AL., et al. 2006. J Lipid Res. 47: 2551-61. PMID: 16926441
- PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle. | Remels, AH., et al. 2009. Am J Physiol Endocrinol Metab. 297: E174-83. PMID: 19417127
- Angiogenic response of advanced glycation end products (AGEs) involves PPARgamma. | Devi, MS. and Sudhakaran, PR. 2012. Indian J Biochem Biophys. 49: 18-24. PMID: 22435140
- Effects of structural and electronic characteristics of chalcones on the activation of peroxisome proliferator-activated receptor gamma. | Schott, JT., et al. 2013. Chem Pharm Bull (Tokyo). 61: 229-36. PMID: 23183544
- Peroxisome proliferator-activated receptor-γ activation inhibits hepatocellular carcinoma cell invasion by upregulating plasminogen activator inhibitor-1. | Pang, X., et al. 2013. Cancer Sci. 104: 672-80. PMID: 23461356
- Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. | Lackey, DE., et al. 2013. Am J Physiol Endocrinol Metab. 304: E1175-87. PMID: 23512805
- Peroxisome proliferator-activated receptor-gamma activation attenuates diabetic cardiomyopathy via regulation of the TGF-β/ERK pathway and epithelial-to-mesenchymal transition. | Yan, XL., et al. 2018. Life Sci. 213: 269-278. PMID: 30189217
- Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity. | Li, S., et al. 2020. Ecotoxicol Environ Saf. 201: 110801. PMID: 32502906
- Combination of Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Agonist and PPAR Gamma Co-Activator 1α (PGC-1α) Activator Ameliorates Cognitive Deficits, Oxidative Stress, and Inflammation in Rodent Model of Parkinson's Disease. | Das, NR., et al. 2021. Curr Neurovasc Res. 18: 497-507. PMID: 34923943
Inhibitor of:
Angiogenesis.Activator of:
EG545948, netrin-1, PPAR gamma, and SDR42E1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW 1929, 1 mg | sc-202640 | 1 mg | $89.00 |