PP1β Activators
PP1β activators are a class of chemical compounds that play a crucial role in modulating cellular processes by specifically targeting and activating protein phosphatase 1 beta (PP1β). PP1β is a member of the protein phosphatase 1 (PP1) family, which is a key enzyme involved in the dephosphorylation of various proteins within cells. Phosphorylation is a reversible post-translational modification that regulates the activity of numerous proteins and signaling pathways. PP1β activators work by enhancing the catalytic activity of PP1β, ultimately leading to the removal of phosphate groups from specific target proteins. This dephosphorylation process serves as a critical regulatory mechanism in controlling various cellular processes, including cell cycle progression, gene expression, and signal transduction.
The activation of PP1β by these chemical compounds occurs through a highly specific interaction with the enzyme's active site. This interaction induces a conformational change in PP1β, resulting in an increased enzymatic activity that facilitates the dephosphorylation of substrates. By selectively activating PP1β, these activators can fine-tune the phosphorylation status of target proteins, thereby influencing the cellular responses to different stimuli. The discovery and characterization of PP1β activators have provided valuable insights into the intricate molecular mechanisms governing cellular signaling and regulation. Understanding how these compounds work at the molecular level is essential for unraveling the complexity of cellular processes and advancing our knowledge of biological systems.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is known to activate adenylate cyclase, leading to an increase in cAMP levels within cells. Elevated cAMP has been associated with enhanced expression of various proteins through the PKA pathway, potentially including PP1β. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, plays a crucial role in cellular differentiation and proliferation. It has been shown to regulate the expression of numerous genes, and may influence the expression of PP1β indirectly through modulation of signaling pathways. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that can modulate the expression of genes through interaction with glucocorticoid receptors. The activation of these receptors has been linked to changes in the expression of various proteins, including potentially PP1β. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin, a hormone critical for glucose metabolism, has been shown to influence the expression and activity of various proteins through the PI3K/Akt signaling pathway. The modulation of this pathway could potentially affect the expression of PP1β. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $100.00 | 6 | |
Hydrocortisone, another glucocorticoid, modulates gene expression through its interaction with glucocorticoid receptors. This interaction may potentially lead to changes in the expression levels of PP1β, among other proteins. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine has been shown to influence cellular signaling pathways and modulate the activity of various proteins. Its potential role in inducing the expression of PP1β may be related to its ability to alter intracellular cAMP levels and subsequent activation of associated signaling pathways. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 plays a vital role in calcium homeostasis and bone metabolism. It influences gene expression through its active form, calcitriol, which interacts with the vitamin D receptor. This interaction can potentially affect the expression of PP1β as part of its regulatory effects on cellular function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a compound found in turmeric, has been shown to modulate the activity of various signaling pathways and influence gene expression. Its potential effect on PP1β expression could be mediated through its anti-inflammatory and antioxidant properties. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol found in grapes and berries, is known to activate SIRT1, a sirtuin that influences cellular lifespan and metabolism. Activation of SIRT1 has been linked to changes in the expression of various proteins, potentially including PP1β. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride has been used in studies related to mood disorders and has been shown to influence various signaling pathways. Its potential effect on PP1β expression could be related to its modulation of intracellular signaling and gene expression. | ||||||