POTE18 Activators
POTE ankyrin domain family member 18 (POTE18) is a protein encoded by the POTE18 gene located within a cluster of POTE paralogs on chromosome 2. The POTE gene family is characterized by its expression predominantly in reproductive tissues, such as the testis and ovary, and in various cancers. POTE18, like its family members, is presumed to have roles in the processes of cell growth and division due to its expression profile.
The protein structure of POTE18 is predicted to contain ankyrin repeats, a common protein-protein interaction motif found in various types of proteins. These ankyrin repeats are involved in mediating interactions with other proteins and are crucial for a wide range of cellular functions, including signaling, cell cycle control, and the regulation of transcription and translation. Given the presence of these domains, POTE18 is thought to participate in similar interactions, although the specific partners and biological pathways it impacts remain to be elucidated.In cancer biology, the expression of POTE genes is of interest due to their cancer-testis antigen status, meaning they are silent in most normal tissues except for the testes, but are activated in various cancers. This makes POTE18 a potential biomarker for certain cancers and a possible target for cancer immunotherapy. The expression of POTE genes in cancers suggests they may have roles in the aberrant cellular proliferation characteristic of tumorigenesis.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, a metabolite of Vitamin A, influences gene expression and cellular differentiation, which could indirectly affect POTE18 if it's involved in these processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a polyphenol found in green tea, has broad biological activities, including effects on gene expression and signal transduction pathways that might intersect with POTE18's function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels, which can indirectly influence POTE18 activity if it's involved in cAMP-dependent signaling pathways. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine can influence gene expression patterns, which might affect POTE18 activity if it's involved in epigenetically regulated processes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, affects chromatin remodeling and gene expression, potentially impacting POTE18 activity if linked to these pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, can alter various cellular pathways, potentially influencing POTE18 activity if it is involved in pathways regulated by mTOR. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
As a PI3K inhibitor, LY294002 could affect POTE18 activity if it's involved in PI3K/Akt signaling pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
This histone deacetylase inhibitor can influence chromatin structure and gene expression, potentially affecting POTE18 activity if it's involved in such regulatory processes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a compound in turmeric, influences a wide range of cellular processes, including inflammation and oxidative stress responses, which could affect POTE18 if involved in these pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol in red wine, is known for its effects on sirtuin activation and gene expression, potentially impacting POTE18 activity if linked to these mechanisms. | ||||||