Potassium Channel Modulators
Items 51 to 60 of 103 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cibenzoline | 53267-01-9 | sc-268718 | 10 mg | $209.00 | ||
Cibenzoline functions as a potassium channel modulator by selectively binding to the channel's regulatory sites, which alters its conformational state. This modulation affects the kinetics of ion permeation, enhancing the selectivity and efficiency of potassium ion transport. Its unique molecular structure promotes specific interactions with channel subunits, influencing the overall ion flow dynamics and contributing to the intricate balance of cellular membrane potential. | ||||||
(−)-Bicuculline methochloride | 53552-05-9 | sc-203528 sc-203528A sc-203528B | 10 mg 50 mg 500 mg | $138.00 $635.00 $5200.00 | ||
(-)-Bicuculline methochloride acts as a potassium channel modulator by interacting with specific binding sites on the channel, leading to alterations in ion conductance. Its unique stereochemistry allows for selective inhibition of certain potassium currents, impacting the channel's gating mechanisms. This compound's ability to stabilize distinct conformations of the channel influences the kinetics of ion flux, thereby affecting cellular excitability and signaling pathways. | ||||||
P1075 | 60559-98-0 | sc-203657 sc-203657A | 10 mg 50 mg | $205.00 $860.00 | 1 | |
P1075 functions as a potassium channel modulator through its unique ability to engage with allosteric sites on the channel protein, resulting in nuanced changes to ion permeability. Its structural characteristics facilitate selective modulation of channel activity, influencing the voltage-dependent gating dynamics. By altering the conformational landscape of the channel, P1075 can fine-tune the kinetics of ion transport, thereby impacting cellular membrane potential and excitability. | ||||||
Gabapentin-lactam | 64744-50-9 | sc-201003 sc-201003A | 50 mg 250 mg | $70.00 $205.00 | ||
Gabapentin-lactam acts as a potassium channel modulator by selectively binding to specific sites on the channel, leading to alterations in ion flow and channel conductance. Its unique molecular structure promotes distinct interactions with the lipid bilayer, enhancing stability and influencing gating mechanisms. This compound exhibits a capacity to modify the activation and inactivation kinetics of potassium channels, thereby affecting the overall ionic balance within cellular environments. | ||||||
Nicorandil | 65141-46-0 | sc-200995 sc-200995B sc-200995A sc-200995C | 50 mg 100 mg 250 mg 1 g | $57.00 $98.00 $240.00 $500.00 | 4 | |
Nicorandil functions as a potassium channel modulator through its dual action on ATP-sensitive potassium channels and nitric oxide pathways. Its unique nitro group facilitates the release of nitric oxide, promoting vasodilation. The compound's ability to stabilize the open state of potassium channels enhances ion permeability, influencing cellular excitability. Additionally, its interactions with membrane lipids can alter channel dynamics, impacting signal transduction and cellular homeostasis. | ||||||
Adenylyl-imidodiphosphate Lithium Salt Hydrate | 25612-73-1 | sc-203805 | 25 mg | $358.00 | 1 | |
Adenylyl-imidodiphosphate Lithium Salt Hydrate acts as a potassium channel modulator by mimicking ATP, influencing channel gating and ion flow. Its unique structure allows for specific interactions with nucleotide-binding sites, enhancing the stability of open channel conformations. This compound can alter the kinetics of channel activation and inactivation, thereby affecting cellular signaling pathways. Its hydrophilic nature also facilitates solubility, promoting effective molecular interactions within cellular environments. | ||||||
CyPPA | 73029-73-9 | sc-205281 sc-205281A | 10 mg 50 mg | $145.00 $645.00 | ||
CyPPA functions as a potassium channel modulator by selectively binding to specific sites on the channel protein, altering its conformational dynamics. This compound exhibits unique electrostatic interactions that stabilize the open state of the channel, enhancing ion permeability. Its distinct molecular architecture influences the rate of channel activation and deactivation, thereby modulating the flow of potassium ions. Additionally, CyPPA's lipophilic characteristics contribute to its membrane permeability, facilitating its interaction with lipid bilayers. | ||||||
α-Dendrotoxin | 74504-53-3 | sc-252333 | 0.1 mg | $428.00 | ||
α-Dendrotoxin acts as a potassium channel modulator by specifically targeting and binding to voltage-gated potassium channels, particularly the Kv1 family. This binding induces conformational changes that inhibit channel activity, effectively blocking potassium ion flow. Its unique structure allows for high-affinity interactions with channel subunits, influencing gating kinetics and prolonging action potential duration. The toxin's selective affinity and interaction dynamics play a crucial role in neuronal excitability modulation. | ||||||
Minoxidil sulfate (U-58838) | 83701-22-8 | sc-200987 sc-200987A sc-200987B sc-200987C | 5 mg 25 mg 100 mg 1 g | $153.00 $315.00 $490.00 $969.00 | ||
Minoxidil sulfate (U-58838) functions as a potassium channel modulator by selectively interacting with ATP-sensitive potassium channels. Its unique chemical structure facilitates binding that alters channel conductance, impacting ion permeability. This modulation affects cellular excitability and can influence various signaling pathways. The compound exhibits distinct reaction kinetics, with a notable ability to stabilize channel states, thereby affecting the overall ion homeostasis within cells. | ||||||
(±)-Cromakalim | 94470-67-4 | sc-217958 | 25 mg | $428.00 | ||
(±)-Cromakalim acts as a potassium channel modulator by engaging with ATP-sensitive potassium channels, promoting channel opening and enhancing potassium ion efflux. Its unique stereochemistry allows for differential interactions with channel subunits, influencing gating dynamics. This compound exhibits rapid kinetics, facilitating swift alterations in membrane potential and cellular excitability. Additionally, its lipophilic nature aids in membrane penetration, further modulating ion transport mechanisms. | ||||||