Nicorandil (CAS 65141-46-0)
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Nicorandil is a small molecule K(ATP) channel opener, producing relaxation of coronary vascular smooth muscle and vasodilation. Specific binding of Nicorandil to the C-terminus of the SUR2B K(ATP) channel generates K+ flux and hyperpolarization of the surface membrane, producing consequent closure of voltage-dependent ion channels and reduction of intracellular free Ca2+. Nicorandil stimulates guanylyl cyclase and increases cyclic GMP levels in correlation with the activation of K(ATP) channels. Nicorandil is described to protect against ischemia-induced ventricular arrhythmia by upregulating endothelial nitric oxide synthase (eNOS) expression. Nicorandil is also described to suppress mitochondrial permeability transition triggered by oxidative stress resulting from ischemia-reperfusion, preventing mitochondrial calcium uptake/overload and oxidative damage. Donation of NO from Nicorandil is also described.
Nicorandil (CAS 65141-46-0) References
- Molecular mechanism of action of nicorandil. | Kukovetz, WR., et al. 1992. J Cardiovasc Pharmacol. 20 Suppl 3: S1-7. PMID: 1282168
- Pharmacokinetic profile of nicorandil in humans: an overview. | Frydman, A. 1992. J Cardiovasc Pharmacol. 20 Suppl 3: S34-44. PMID: 1282174
- Clinical profile of nicorandil: an overview of its hemodynamic properties and therapeutic efficacy. | Krumenacker, M. and Roland, E. 1992. J Cardiovasc Pharmacol. 20 Suppl 3: S93-102. PMID: 1282184
- Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction. | Horinaka, S., et al. 2004. Cardiovasc Drugs Ther. 18: 13-22. PMID: 15115899
- Impact of a single intravenous administration of nicorandil before reperfusion in patients with ST-segment-elevation myocardial infarction. | Ishii, H., et al. 2005. Circulation. 112: 1284-8. PMID: 16116055
- Nicorandil suppresses the increases in plasma level of matrix metalloproteinase activity and attenuates left ventricular remodeling in patients with acute myocardial infarction. | Fujiwara, T., et al. 2007. Heart Vessels. 22: 303-9. PMID: 17879021
- Species differences in percutaneous absorption of nicorandil. | Sato, K., et al. 1991. J Pharm Sci. 80: 104-7. PMID: 1828835
- Nicorandil protects cardiac mitochondria against permeability transition induced by ischemia-reperfusion. | Carreira, RS., et al. 2008. J Bioenerg Biomembr. 40: 95-102. PMID: 18415669
- Effects of nicorandil on cardiovascular events in patients with coronary artery disease in the Japanese Coronary Artery Disease (JCAD) study. | Horinaka, S., et al. 2010. Circ J. 74: 503-9. PMID: 20081320
- Nicorandil increases coronary blood flow predominantly by K-channel opening mechanism. | Yoneyama, F., et al. 1990. Cardiovasc Drugs Ther. 4: 1119-26. PMID: 2150593
- Vasodilative effect of nicorandil on coronary artery. | Miyazaki, Y., et al. 1985. Arzneimittelforschung. 35: 504-7. PMID: 3158319
- Therapeutic potential of potassium channel activators in coronary heart disease. | Haeusler, G. and Lues, I. 1994. Eur Heart J. 15 Suppl C: 82-8. PMID: 7995277
- SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. | Shindo, T., et al. 1998. Br J Pharmacol. 124: 985-91. PMID: 9692785
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicorandil, 50 mg | sc-200995 | 50 mg | $57.00 | |||
Nicorandil, 100 mg | sc-200995B | 100 mg | $98.00 | |||
Nicorandil, 250 mg | sc-200995A | 250 mg | $240.00 | |||
Nicorandil, 1 g | sc-200995C | 1 g | $500.00 |