Molecular structure of (±)-Cromakalim, CAS Number: 94470-67-4
(±)-Cromakalim (CAS 94470-67-4)
Application:
(±)-Cromakalim is a prototypical Kir6 (KATP) channel activator
CAS Number:
94470-67-4
Molecular Weight:
286.33
Molecular Formula:
C16H18N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)-Cromakalim, also known as Cromakalim or BRL 34915, is a KIR6.x (KATP) channel activator. It exhibits significant effects on various physiological systems.Its primary action involves activating ATP-sensitive potassium channels, specifically the SUR2-Kir6 variant. (±)-Cromakalim has been found to have anti-ischemic and cardioprotective properties in rat hearts. At a concentration of 8.9 μM, it demonstrates anti-ischemic effects, while its cardioprotective effects manifest at an even lower concentration of 0.03 μM. It has served as useful for studying potassium channel biology and has been used as a basis for developing more selective K+ channel openers.
(±)-Cromakalim (CAS 94470-67-4) References
- Effects of chronic treatment with cromakalim and glibenclamide in alloxan-induced diabetic rats. | Kulkarni, JS., et al. 2002. Pharmacol Res. 46: 101-5. PMID: 12220947
- Recent developments in the chemistry of potassium channel activators: the cromakalim analogs. | Sebille, S., et al. 2004. Curr Med Chem. 11: 1213-22. PMID: 15134515
- Time-dependent alteration in cromakalim-induced relaxation of corpus cavernosum from streptozocin-induced diabetic rats. | Ghasemi, M., et al. 2007. Life Sci. 81: 960-9. PMID: 17825847
- New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers. | Sebille, S., et al. 2008. Bioorg Med Chem. 16: 5704-19. PMID: 18406154
- Cromakalim activates the K(ATP) and enhances spontaneous transient outward potassium currents in rat saphenous arterial myocytes. | Fioretti, B., et al. 2008. Pharmacol Res. 57: 398-402. PMID: 18501626
- Prevention of cerebral vasospasm by local delivery of cromakalim with a biodegradable controlled-release system in a rat model of subarachnoid hemorrhage. | Omeis, I., et al. 2009. J Neurosurg. 110: 1015-20. PMID: 19119878
- The haemodynamic profile of cromakalim in the cat. | Clapham, JC. and Buckingham, RE. 1988. J Cardiovasc Pharmacol. 12: 555-61. PMID: 2468055
- Butylidenephthalide antagonizes cromakalim-induced systolic pressure reduction in conscious normotensive rats. | Shih, CH., et al. 2015. BMC Complement Altern Med. 15: 344. PMID: 26438097
- Tolerance to cromakalim in the rat uterus in vivo. | Downing, SJ., et al. 1989. Br J Pharmacol. 96: 732-8. PMID: 2720301
- Analogs of the ATP-Sensitive Potassium (KATP) Channel Opener Cromakalim with in Vivo Ocular Hypotensive Activity. | Roy Chowdhury, U., et al. 2016. J Med Chem. 59: 6221-31. PMID: 27367033
- Cromakalim, a Potassium Channel Opener, Ameliorates the Organophosphate and Carbamate-Induced Seizure in Mice. | Ostadhadi, S., et al. 2018. Acta Med Iran. 56: 14-20. PMID: 29436790
- Mechanical and energetic effects of cromakalim on guinea pig left ventricular papillary muscle. | Joseph, T., et al. 1996. J Pharmacol Exp Ther. 279: 464-71. PMID: 8930147
- Effect of cromakalim on the purinergic and cholinergic transmission in the rat detrusor muscle. | Boselli, C., et al. 1997. Eur J Pharmacol. 335: 23-30. PMID: 9371542
Inhibitor of:
KCNRG.Activator of:
KCNE4, KIR6.1, KIR6.2, MaxiKα, Potassium Chloride, and Shaker.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-Cromakalim, 25 mg | sc-217958 | 25 mg | $428.00 |