Adenylyl-imidodiphosphate Lithium Salt Hydrate (CAS 25612-73-1)

Adenylyl-imidodiphosphate lithium salt hydrate is a synthetic analogue of adenosine triphosphate (ATP) designed for biochemical research. Its modification renders Adenylyl-imidodiphosphate resistant to hydrolysis by ATPases, making it a non-hydrolyzable ATP analogue. Adenylyl-imidodiphosphate lithium salt hydrate is valuable in studies of enzymatic mechanisms involving ATP-dependent enzymes. Since it cannot be hydrolyzed, it acts as an ATP mimic that binds to enzymes but does not support reactions requiring ATP hydrolysis. This allows researchers to investigate the role of ATP binding in enzyme activation, substrate binding, and the initial steps of catalytic action without progressing through the entire reaction cycle. This compound is widely used in the study of motor proteins, such as myosins, kinesins, and dyneins, which rely on ATP hydrolysis to move along cytoskeletal filaments. Furthermore, Adenylyl-imidodiphosphate lithium salt hydrate is applicable in the study of signal transduction pathways, DNA replication, and protein synthesis processes.