α-Dendrotoxin (CAS 74504-53-3)
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α-Dendrotoxin is a peptide toxin that is found in the venom of the green mamba snake (Dendroaspis angusticeps). It is known for its ability to block specific voltage-gated potassium channels (Kv1 channels), particularly Kv1.1, Kv1.2, and Kv1.6, which are widely distributed in the central and peripheral nervous systems. In research, α-Dendrotoxin is employed to study potassium channels, providing insights into their role in regulating neuronal excitability and the release of neurotransmitters. The toxin′s specificity for certain Kv1 channels makes it useful for distinguishing between different channel subtypes and for probing their distribution and function within neural tissues. Additionally, α-Dendrotoxin is used in the development of assays to screen for potential modulators of potassium channel activity, contributing to the understanding of how modulation of these ion channels can influence cellular and organismal functions.
α-Dendrotoxin (CAS 74504-53-3) References
- Effects of alpha-dendrotoxin and dendrotoxin K on extracellular excitatory amino acids and on electroencephalograph spectral power in the hippocampus of anaesthetised rats. | Richards, DA., et al. 2000. Neurosci Lett. 293: 183-6. PMID: 11036191
- Modulation of excitability by alpha-dendrotoxin-sensitive potassium channels in neocortical pyramidal neurons. | Bekkers, JM. and Delaney, AJ. 2001. J Neurosci. 21: 6553-60. PMID: 11517244
- Production of seizures and brain damage in rats by alpha-dendrotoxin, a selective K+ channel blocker. | Bagetta, G., et al. 1992. Neurosci Lett. 139: 34-40. PMID: 1357602
- Crystal structure of alpha-dendrotoxin from the green mamba venom and its comparison with the structure of bovine pancreatic trypsin inhibitor. | Skarzyński, T. 1992. J Mol Biol. 224: 671-83. PMID: 1373774
- Inhibition of chloroplast ATPase by the K+ channel blocker alpha-dendrotoxin. | Schulenburg, P., et al. 1992. Eur J Biochem. 210: 257-67. PMID: 1446675
- Altered expression of potassium channel subunit mRNA and alpha-dendrotoxin sensitivity of potassium currents in rat dorsal root ganglion neurons after axotomy. | Yang, EK., et al. 2004. Neuroscience. 123: 867-74. PMID: 14751280
- Effects of alpha-dendrotoxin on K+ currents and action potentials in tetrodotoxin-resistant adult rat trigeminal ganglion neurons. | Yoshida, S. and Matsumoto, S. 2005. J Pharmacol Exp Ther. 314: 437-45. PMID: 15831438
- Homologues of a K(+) channel blocker ?-dendrotoxin: characterization of synaptosomal binding sites and their coupling to elevation of cytosolic free calcium concentration. | Muniz, ZM., et al. 1990. Neurochem Int. 16: 105-12. PMID: 20504547
- α-Dendrotoxin inhibits the ASIC current in dorsal root ganglion neurons from rat. | Báez, A., et al. 2015. Neurosci Lett. 606: 42-7. PMID: 26314509
- Α-Dendrotoxin-sensitive Kv1 channels contribute to conduction failure of polymodal nociceptive C-fibers from rat coccygeal nerve. | Wang, XC., et al. 2016. J Neurophysiol. 115: 947-57. PMID: 26609114
- The alpha-dendrotoxin footprint on a mammalian potassium channel. | Tytgat, J., et al. 1995. J Biol Chem. 270: 24776-81. PMID: 7559595
- Hippocampal damage produced in rats by alpha-dendrotoxin--a selective K+ channel blocker--involves non-NMDA receptor activation. | Bagetta, G., et al. 1994. Neurochem Int. 24: 81-90. PMID: 8130739
- Selective block by alpha-dendrotoxin of the K+ inward rectifier at the Vicia guard cell plasma membrane. | Obermeyer, G., et al. 1994. J Membr Biol. 137: 249-59. PMID: 8182733
- Primary structure of a potassium channel toxin from the sea anemone Actinia equina. | Minagawa, S., et al. 1998. FEBS Lett. 427: 149-51. PMID: 9613617
- Delineation of the functional site of alpha-dendrotoxin. The functional topographies of dendrotoxins are different but share a conserved core with those of other Kv1 potassium channel-blocking toxins. | Gasparini, S., et al. 1998. J Biol Chem. 273: 25393-403. PMID: 9738007
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Dendrotoxin, 0.1 mg | sc-252333 | 0.1 mg | $428.00 | |||
| US: Only available in the US | ||||||