Minoxidil sulfate (U-58838) (CAS 83701-22-8)
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Minoxidil sulfate is a compound that functions as a potassium channel opener, specifically by activating ATP-sensitive potassium channels in vascular smooth muscle cells. This activation leads to hyperpolarization of the cell membrane, which in turn inhibits calcium influx and causes relaxation of vascular smooth muscle. Minoxidil sulfate is able to dilate arterioles and reduce peripheral vascular resistance. This mechanism of action is attributed to its ability to promote vasodilation and increase blood flow, making it a relevant compound in studies focusing on cardiovascular function and regulation. At the molecular level, minoxidil sulfate interacts with potassium channels to modulate their activity, ultimately influencing vascular tone and blood pressure regulation. Its role in experimental contexts involves investigating the physiological and pharmacological effects of vasodilators and their impact on cardiovascular function.
Minoxidil sulfate (U-58838) (CAS 83701-22-8) References
- Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models. | Black, KL., et al. 2008. Brain Res. 1227: 198-206. PMID: 18602898
- Ionic and secretory response of pancreatic islet cells to minoxidil sulfate. | Antoine, MH., et al. 1991. J Pharmacol Exp Ther. 258: 286-91. PMID: 2072300
- Minoxidil sulfate is the active metabolite that stimulates hair follicles. | Buhl, AE., et al. 1990. J Invest Dermatol. 95: 553-7. PMID: 2230218
- Minoxidil sulfate induced the increase in blood-brain tumor barrier permeability through ROS/RhoA/PI3K/PKB signaling pathway. | Gu, YT., et al. 2013. Neuropharmacology. 75: 407-15. PMID: 23973310
- Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle. | Winquist, RJ., et al. 1989. J Pharmacol Exp Ther. 248: 149-56. PMID: 2464055
- Electrophysiological mechanisms of minoxidil sulfate-induced vasodilation of rabbit portal vein. | Leblanc, N., et al. 1989. Circ Res. 65: 1102-11. PMID: 2791221
- The effect of topical minoxidil treatment on follicular sulfotransferase enzymatic activity. | Goren, A., et al. 2018. J Biol Regul Homeost Agents. 32: 937-940. PMID: 30043580
- Low-dose daily aspirin reduces topical minoxidil efficacy in androgenetic alopecia patients. | Goren, A., et al. 2018. Dermatol Ther. 31: e12741. PMID: 30226287
- Effect of Minoxidil on Trabecular Outflow via the Paracellular Pathway. | Kang, HG. and Kim, JW. 2020. Korean J Ophthalmol. 34: 97-105. PMID: 32233142
- Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability. | Meisheri, KD., et al. 1988. J Pharmacol Exp Ther. 245: 751-60. PMID: 3385640
- Biochemical mechanisms by which minoxidil sulfate influences mammalian cells. | Meisheri, KD. and Cipkus, LA. 1987. Dermatologica. 175 Suppl 2: 3-11. PMID: 3691912
- Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells. | Nakaya, Y., et al. 1994. J Dermatol Sci. 7 Suppl: S104-8. PMID: 7999667
- The same enzymes catalyze sulfation of minoxidil, minoxidil analogs and catecholamines. | Singer, SS. 1994. Chem Biol Interact. 92: 33-45. PMID: 8033267
- Stimulation of Cl conductance by minoxidil sulfate and K conductance by minoxidil in eccrine clear cells. | Ohtsuyama, M., et al. 1994. J Pharmacol Exp Ther. 269: 823-31. PMID: 8182551
- Ba2+ differentially inhibits the Rb+ efflux promoting and the vasorelaxant effects of levcromakalim and minoxidil sulfate in rat isolated aorta. | Quast, U., et al. 1995. Naunyn Schmiedebergs Arch Pharmacol. 353: 86-93. PMID: 8750921
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Minoxidil sulfate (U-58838), 5 mg | sc-200987 | 5 mg | $153.00 | |||
Minoxidil sulfate (U-58838), 25 mg | sc-200987A | 25 mg | $315.00 | |||
Minoxidil sulfate (U-58838), 100 mg | sc-200987B | 100 mg | $490.00 | |||
Minoxidil sulfate (U-58838), 1 g | sc-200987C | 1 g | $969.00 |