POM121 Activators
POM121 activators encompass a range of chemical compounds that indirectly enhance the functional activity of the nuclear pore complex protein POM121 across various signaling pathways. For instance, Forskolin and Ionomycin augment intracellular levels of cAMP and calcium, respectively, leading to the activation of PKA and calcium-dependent kinases. These activated kinases may directly phosphorylate POM121 or other associated proteins, thus potentially enhancing the assembly and functionality of the nuclear pore complex. Similarly, PMA, as a PKC activator, and Vinblastine, which disrupts microtubule dynamics, might indirectly enhance the nuclear localization and incorporation of POM121 into the nuclear envelope. This process is crucial for maintaining the nucleocytoplasmic transport that POM121 facilitates. The phosphorylation state of POM121 and its associated complex is critical, with compounds like Calyculin A, Okadaic Acid, and Bisindolylmaleimide I, increasing phosphorylation through inhibition of protein phosphatases or modulation of PKC activity, thus promoting the enhancement of POM121's role in nuclear transport.
Continuing, compounds such as Amiloride affect ionic balance, which might influence the activity of ion-sensitive kinases that regulate POM121. Epigallocatechin gallate, by inhibiting specific kinases, and Sphingosine-1-phosphate, through its receptor-mediated signaling, could alter the phosphorylation landscape of nuclear pore complex proteins, including POM121, facilitating its transport function. Anisomycin's role in activating stress-activated protein kinases and Staurosporine's broad-spectrum kinase inhibition might lead to altered phosphorylation patterns that inadvertently result in the upregulation of compensatory pathways, enhancing POM121 activity. Collectively, these chemicals interact with a network of cellular signaling pathways that converge on the nuclear pore complex, indirectly enhancing the functional activity of POM121 without the need for direct binding or upregulation of expression, thereby sustaining the essential processes of nucleocytoplasmic transport.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels within the cell. Elevated cAMP activates PKA, which can phosphorylate nuclear pore complex proteins such as POM121, potentially enhancing its nuclear import functionality. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a PKC activator which modulates the phosphorylation state of many proteins. PKC has been implicated in the phosphorylation of nucleoporins, which could enhance the nuclear pore complex assembly and function where POM121 is a key component. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations, thereby activating calcium-dependent protein kinases which may phosphorylate nuclear pore proteins including POM121, potentially enhancing its function. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $56.00 | 6 | |
Amiloride indirectly increases intracellular sodium levels, which may influence the phosphorylation state of proteins through kinases sensitive to ionic changes, thereby affecting POM121's role in nuclear transport. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins. It may increase the phosphorylation state of POM121, potentially enhancing its nuclear transport capabilities. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is another inhibitor of protein phosphatases 1 and 2A, similar to Calyculin A, which could lead to enhanced phosphorylation and activity of nuclear pore complex proteins including POM121. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that might alter the activity of kinases implicated in nucleocytoplasmic transport, potentially enhancing the functional activity of POM121 by modulating its phosphorylation state. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that activates a family of G-protein-coupled receptors, which can lead to the phosphorylation of various proteins. This signaling may influence the function of nuclear pore complexes and POM121. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor which also activates stress-activated protein kinases. This can lead to a cellular response that modifies the phosphorylation state of nuclear pore components including POM121. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC. Inhibition of PKC can disrupt normal protein phosphorylation balance, potentially enhancing the activity of POM121 through compensatory phosphorylation mechanisms. | ||||||