POLR2K Activators
POLR2K is a gene that encodes a vital subunit of RNA polymerase II, the principal enzyme implicated in the transcription of DNA into messenger RNA in eukaryotic cells. This polymerase engages in the critical task of transcribing genomic DNA into RNA templates, which are then translated into proteins that perform a multitude of functions within the cell. The POLR2K subunit, while small, is integral to the assembly and stability of the polymerase complex and is essential for the initiation phase of gene transcription. Understanding the regulation of POLR2K is crucial for comprehending how genes are expressed and controlled within the cell. Despite its diminutive size, the POLR2K protein plays an indispensable role in the precise orchestration of gene expression, serving as a fundamental cog in the transcriptional machinery.
Various chemical compounds have been identified that can potentially induce the expression of POLR2K. These activators interact with cellular pathways to upregulate gene transcription. Compounds like Retinoic Acid and Beta-estradiol can bind to their respective receptors, leading to the recruitment of coactivators and the subsequent upregulation of gene expression, including the expression of POLR2K. Other molecules, such as the green tea component Epigallocatechin gallate (EGCG), may interact with antioxidant response elements to stimulate POLR2K expression. Furthermore, Forskolin, by increasing intracellular cAMP, can activate protein kinase A, which may phosphorylate transcription factors that drive POLR2K expression. Histone deacetylase inhibitors such as Trichostatin A and Sodium Butyrate can alter chromatin structure, facilitating access to transcription factors that increase POLR2K transcription. Additionally, compounds like 5-Azacytidine and Hydroxyurea can initiate a cellular stress response, potentially leading to the enhanced expression of genes associated with DNA repair, including POLR2K. These compounds and their interactions with cellular mechanisms provide a rich avenue for research into the regulation of gene expression and the complex web of intracellular signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, through its interaction with retinoic acid receptors, can initiate transcriptional changes by triggering the disassembly of repressor complexes on gene promoters, potentially leading to an upsurge in POLR2K expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
As a prominent catechin in green tea, Epigallocatechin Gallate may prompt antioxidant response elements within the promoter regions of genes, which could result in the enhanced transcription of POLR2K. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By raising intracellular cAMP levels, Forskolin can activate protein kinase A (PKA), which in turn can phosphorylate transcription factors, possibly stimulating an increase in the transcription of the POLR2K gene. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA, a potent activator of protein kinase C (PKC), can lead to the transcriptional activation of immediate-early genes, which may include POLR2K, through the PKC signaling cascade. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, by inhibiting histone deacetylase, could result in an open chromatin configuration around the POLR2K gene, facilitating its transcriptional activation by allowing transcription factor binding. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a cytidine analog, 5-Azacytidine can be incorporated into DNA, resulting in the inhibition of methylation. DNA demethylation around the POLR2K gene locus might lead to its transcriptional upsurge. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate's inhibition of histone deacetylases can enhance histone acetylation, creating an active chromatin state that may elevate POLR2K gene transcription. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol binding to estrogen receptors can result in the recruitment of coactivators to estrogen-responsive elements near genes like POLR2K, potentially increasing their transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Through the inhibition of GSK-3, Lithium Chloride can stimulate the Wnt signaling pathway, which might culminate in the transcriptional activation of the POLR2K gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to stimulate the expression of genes by activating transcription factors such as NF-kB, which could lead to the upregulation of POLR2K expression. | ||||||