POLR2J3 Activators
The assemblage of chemicals classified as POLR2J3 Activators comprises a diverse range of compounds that are primarily involved in the indirect enhancement of the transcriptional activity of RNA polymerase II, to which POLR2J3 belongs. This enhancement is postulated to occur through the modulation of chromatin structure and the transcriptional machinery, thereby facilitating an increase in gene expression. The activators include several histone deacetylase inhibitors like Trichostatin A, Sodium butyrate, Vorinostat, and Phenylbutyrate.
Further, agents such as 5-Azacytidine and Anacardic acid can lead to alterations in the chromatin landscape through effects on DNA methylation and histone acetylation, respectively. S-Adenosylmethionine serves as a universal methyl donor in various biochemical pathways and can influence methylation patterns that affect transcription factor binding and, subsequently, POLR2J3 activity. Additionally, compounds like Beta-estradiol, Caffeic acid phenethyl ester, Epigallocatechin gallate, Retinoic acid, and Genistein can impact various signaling cascades and transcription factors that govern the transcriptional regulation of genes, including those transcribed by RNA polymerase II complexes involving POLR2J3.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor that allows for a more relaxed chromatin state, facilitating transcription by POLR2J3. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Inhibits histone acetyltransferase, which can alter chromatin structure to enhance transcription involving POLR2J3. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
A methyl donor for transmethylation reactions, can indirectly support transcriptional activation where POLR2J3 is involved. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
A histone deacetylase inhibitor which can lead to a more open chromatin structure, potentially enhancing POLR2J3 transcriptional activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor, may increase transcription involving POLR2J3 by affecting chromatin accessibility. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
A hormone that can modulate transcription factor activity, possibly leading to an increase in POLR2J3-mediated transcription. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Acts as a histone deacetylase inhibitor, may enhance transcription where POLR2J3 is involved. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $71.00 $296.00 $612.00 | 19 | |
A specific inhibitor of nuclear factor kappa B (NF-κB), which may have a role in transcriptional regulation affecting POLR2J3. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
An antioxidant that may have a role in modulating gene expression, potentially affecting POLR2J3 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A molecule that can regulate gene expression, potentially enhancing POLR2J3-mediated transcription. | ||||||