Date published: 2026-2-23

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PLD6 Activators

PLD6 Activators are a set of chemicals that either directly or indirectly lead to the activation of the PLD6 protein through targeted engagement with specific cellular pathways. These chemicals range in function but share the commonality of affecting intracellular processes, such as small RNA biogenesis, autophagy-related pathways, and stress responses, among others. For example, Forskolin activates adenylyl cyclase, thereby elevating cAMP levels and activating PKA, which can subsequently activate PLD6. Similarly, Curcumin activates AMPK, which then activates ULK1, stimulating autophagy-related pathways that can lead to PLD6 activation. These activators present a broad spectrum of effects on various pathways, offering a valuable toolkit for probing the functional dimensions of PLD6. Resveratrol, for instance, activates SIRT1, a known modulator of miRNA processing, thereby indirectly influencing PLD6. On the other hand, Etoposide induces DNA damage response, which involves ATM kinase activation and can thus activate PLD6 in DNA repair processes. The specificity in action of these chemicals makes them invaluable for understanding the roles and regulatory mechanisms of PLD6 in a cellular context.

Items 1 to 10 of 13 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

D-erythro-Sphingosine

123-78-4sc-3546
sc-3546A
sc-3546B
sc-3546C
sc-3546D
sc-3546E
10 mg
25 mg
100 mg
1 g
5 g
10 g
$90.00
$194.00
$510.00
$2448.00
$9384.00
$15300.00
2
(2)

D-erythro-Sphingosine acts as a substrate for PLD6, engaging in specific molecular interactions that influence lipid metabolism. Its unique structure promotes the formation of bioactive sphingolipids, which play critical roles in cellular signaling pathways. The compound's hydrophobic nature facilitates its integration into lipid membranes, where it can modulate membrane fluidity and organization. Additionally, its reactivity with various enzymes highlights its role in lipid-mediated signaling and cellular responses.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Activates SIRT1, which modulates miRNA processing, indirectly influencing PLD6 activation in small RNA biogenesis.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$78.00
$153.00
$740.00
$1413.00
$2091.00
73
(3)

Activates adenylyl cyclase, elevating cAMP levels and thereby activating PKA, which indirectly promotes PLD6 activation in small RNA pathways.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Activates AMPK, which then activates ULK1, stimulating autophagy-related pathways that can lead to PLD6 activation.

Anisomycin

22862-76-6sc-3524
sc-3524A
5 mg
50 mg
$99.00
$259.00
36
(2)

Activates p38 MAPK, which can induce stress responses leading to PLD6 activation in the context of small RNA regulation.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Up-regulates p53, which can influence the miRNA/siRNA processing pathway, thereby activating PLD6.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Activates RAR, influencing gene transcription pathways that can induce PLD6 activation.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$153.00
$396.00
113
(4)

Activates JNK, stimulating stress-response pathways, which can promote PLD6 activation in RNA biogenesis.

Naringenin

480-41-1sc-219338
25 g
$245.00
11
(1)

Activates PPARγ, which can affect lipid metabolism pathways and lead to the activation of PLD6 in lipid droplet formation.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$51.00
$231.00
$523.00
63
(1)

Induces DNA damage response, activating ATM, which can lead to PLD6 activation in DNA repair processes.