PIWIL1 Inhibitors
PIWIL1 inhibitors belong to a distinctive class of chemical compounds designed to target and impede the activity of PIWIL1, a member of the PIWI (P-element-induced wimpy testis) protein family. PIWIL1, also known as Hiwi, is a crucial component of the PIWI-interacting RNA (piRNA) pathway, playing a pivotal role in the regulation of germ cell development, transposon silencing, and maintenance of genomic integrity. As a part of the Argonaute protein family, PIWIL1 functions by binding to piRNAs, small non-coding RNAs, to form an RNA-induced silencing complex (RISC). This complex actively suppresses the expression of transposable elements within the genome, safeguarding the genetic information in germ cells.
PIWIL1 inhibitors are designed to disrupt this regulatory mechanism by selectively binding to the PIWIL1 protein, thereby hindering its ability to interact with piRNAs and form the functional RISC. This interference in PIWIL1's normal function has the potential to perturb the delicate balance in germ cell development and transposon silencing, providing researchers with a valuable tool to investigate the underlying molecular mechanisms.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Interferes with aldehyde dehydrogenase, altering the cellular redox state which can affect PIWIL1 expression and piRNA pathways. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Binds to DNA and prevents transcription factor binding, potentially downregulating PIWIL1 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor, altering gene expression and possibly reducing PIWIL1 activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor, can lead to increased cellular stress, affecting PIWIL1-related pathways. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
Bromodomain inhibitor, affects transcription and could alter PIWIL1 expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Autophagy inhibitor, could influence degradation pathways associated with PIWIL1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor, can affect protein synthesis pathways, potentially influencing PIWIL1 levels. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules, affects cell division, which could influence PIWIL1 activity in germ cells. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Inhibits transcription of various genes, could reduce PIWIL1 expression. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Hedgehog signaling pathway inhibitor, may indirectly affect PIWIL1 activity. | ||||||