PIST Activators
PIST activators refer to a spectrum of chemical agents that enhance the activity of PIST, also known as PDZ domain-containing protein, which interacts with various proteins including cation-dependent CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) and participates in the trafficking and membrane localization of these proteins. PIST is known to play a role in the tethering of protein complexes to certain cellular compartments, such as the Golgi apparatus, and is involved in regulating the signaling pathways through its interactions.
The activation of PIST by these chemicals may occur through direct binding, which could alter the protein's conformation in a way that increases its affinity for binding partners or enhances its ability to facilitate the assembly of protein complexes. This could lead to an upregulation of the signaling pathways in which PIST is involved, by ensuring that key signaling molecules are correctly positioned within the cell for efficient communication and response to cellular stimuli. Indirect activators might function by influencing the expression levels of PIST, either by upregulating gene transcription or by stabilizing the mRNA to increase protein synthesis. They could also modulate the degradation pathways of PIST, such as ubiquitination and proteasomal degradation, leading to an increased half-life of the protein within the cell. Furthermore, indirect activators may impact other molecular players within the pathways that PIST is known to regulate, thereby enhancing its activity by proxy.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cAMP levels. This can enhance the functional activity of PIST, which is known to interact with cAMP-dependent protein kinase A (PKA). | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterases, thereby increasing cellular cAMP levels. The rise in cAMP can enhance the functional activity of PIST, which interacts with cAMP-dependent protein kinase A (PKA). | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation events. As PIST can be modulated by phosphorylation, this compound could enhance the functional activity of PIST. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation events. As PIST can be modulated by phosphorylation, this compound could enhance the functional activity of PIST. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to adrenergic receptors and increases intracellular cAMP levels. The increase in cAMP can enhance the functional activity of PIST, which interacts with cAMP-dependent protein kinase A (PKA). | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol binds to beta-adrenergic receptors, leading to an increase in cAMP levels. The rise in cAMP can enhance the functional activity of PIST, which interacts with cAMP-dependent protein kinase A (PKA). | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which could lead to phosphorylation and activation of PIST. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that can enhance the functional activity of PIST indirectly by inhibiting kinases that negatively regulate PIST activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates stress-activated protein kinases, leading to increased phosphorylation events. As PIST can be modulated by phosphorylation, this compound could enhance the functional activity of PIST. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits phosphoinositide 3-kinases (PI3Ks), which can enhance PIST activity by limiting negative regulation from PI3K signaling. | ||||||