PIS1 Activators
PIS1 activators are a complex class of compounds that operate across various lipid metabolism pathways to either directly or indirectly stimulate the activity of the PIS1 protein in phosphatidylinositol synthesis. Some activators, such as Oleic Acid and Palmitoyl-CoA, impact PIS1 by escalating the cellular demand for lipids, hence requiring an increased supply of the phosphorylinositol head group that PIS1 transfers. In contrast, inhibitors like U18666A, Rapamycin, and Mevastatin stimulate PIS1 activity by impairing other lipid metabolic pathways, thereby creating a compensatory upregulation of PIS1 to maintain lipid homeostasis.
Furthermore, compounds like Fenofibrate and Wortmannin specifically target enzymes and transcription factors that influence lipid metabolism. Fenofibrate's activation of PPARα and Wortmannin's inhibition of PI3K both result in an increased need for PI synthesis, consequently activating PIS1. Finally, agents like Nystatin and A23187 introduce cellular stress by disrupting membrane integrity or calcium homeostasis, which forces the cell to stabilize its environment. The stabilizing mechanism includes activation of PIS1 to ramp up phosphatidylinositol synthesis. Overall, these chemicals exert precise influences on lipid metabolic pathways, ultimately leading to the activation of PIS1.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Fatty acid that increases cellular lipid demand, thereby activating PIS1 to supplement phosphatidylinositol (PI) synthesis. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $143.00 $510.00 | 2 | |
Inhibits cholesterol transport, thereby indirectly activating PIS1 to maintain lipid homeostasis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, thereby activating autophagy which in turn demands higher PI synthesis, activating PIS1. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Inhibits fatty acid synthase, shifting metabolic focus towards PI synthesis, thereby activating PIS1. | ||||||
Mevastatin (Compactin) | 73573-88-3 | sc-200853 sc-200853A | 10 mg 50 mg | $77.00 $179.00 | 18 | |
Inhibits HMG-CoA reductase, indirectly activating PIS1 to counterbalance lipid synthesis. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Activates PPARα, indirectly upregulating lipid catabolism pathways that will need increased PI synthesis, thereby activating PIS1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor, increases demand for PI substrate, thereby activating PIS1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Another PI3K inhibitor, upregulates PI synthesis and subsequently PIS1 activation. | ||||||
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $51.00 $129.00 $251.00 $3570.00 | 7 | |
Disrupts membrane integrity by binding sterols, compensatorily activating PIS1 for PI synthesis. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
farnesyltransferase inhibitor; alters prenylation pathways and indirectly boosts PIS1 for PI synthesis. | ||||||