PIPK II β Inhibitors
PIPK II β inhibitors belong to a class of chemical compounds that specifically target the PIPK II β enzyme. PIPK II β, or Phosphatidylinositol 5-phosphate 4-kinase type II beta, is an important enzyme involved in the regulation of various cellular processes, primarily associated with lipid metabolism and signal transduction. These inhibitors are designed to modulate the activity of PIPK II β, which plays a pivotal role in the synthesis of phosphoinositide lipids within the cell membrane. Phosphoinositides are essential components of cell membranes and serve as crucial secondary messengers in various intracellular signaling pathways.
PIPK II β inhibitors revolves around their ability to selectively bind to the active site of the PIPK II β enzyme, thereby disrupting its catalytic function. By inhibiting the enzymatic activity of PIPK II β, these compounds interfere with the synthesis of phosphoinositide lipids, which subsequently impacts downstream signaling events. Consequently, PIPK II β inhibitors can modulate cell processes such as membrane trafficking, cytoskeletal rearrangements, and receptor-mediated signaling, among others. Understanding the biochemical properties and structural characteristics of these inhibitors is essential for elucidating their potential applications in the context of cellular biology and signal transduction research, offering valuable insights into the complex regulatory mechanisms governing cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a broad-spectrum inhibitor of the PI3K/Akt pathway, which can indirectly affect PIPK II β activity by altering phosphatidylinositol levels. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a steroidal metabolite that acts as a potent PI3K inhibitor, which may also influence PIPK II β through modulation of downstream phosphatidylinositol phosphate levels. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that inhibits PI3K, affecting the PI3K/Akt pathway and potentially altering PIPK II β activity by influencing the cellular lipid kinase signaling. | ||||||
PIK-93 | 593960-11-3 | sc-364588 | 5 mg | $255.00 | ||
PIK-93 is known to inhibit PI4KIIIβ, which is upstream of PIPK II β, therefore affecting the substrate availability for PIPK II β kinase activity. | ||||||
PI 3-Kβ Inhibitor VI, TGX-221 | 663619-89-4 | sc-203190 | 1 mg | $437.00 | ||
TGX-221 is a selective inhibitor of the PI3K p110β isoform, which may indirectly reduce PIPK II β's substrate availability by altering phosphoinositide signaling. | ||||||
IC-87114 | 371242-69-2 | sc-364509 sc-364509A | 5 mg 50 mg | $140.00 $1060.00 | 1 | |
IC87114 selectively inhibits p110δ, a subunit of PI3K, which could indirectly decrease PIPK II β's activity through its effects on the PI3K/Akt pathway. | ||||||
AS-252424 | 900515-16-4 | sc-202961 sc-202961A | 1 mg 5 mg | $42.00 $158.00 | ||
AS252424 selectively inhibits PI3Kγ, which could lead to downstream effects on PIPK II β by altering PI3K/Akt pathway signaling. | ||||||
ZSTK 474 | 475110-96-4 | sc-475495 | 5 mg | $75.00 | ||
ZSTK474 is a potent PI3K inhibitor, which can indirectly affect PIPK II β activity by modulating the PI3K/Akt pathway and phosphoinositide levels. | ||||||
GSK2126458 | 1086062-66-9 | sc-364503 sc-364503A | 2 mg 10 mg | $265.00 $1050.00 | ||
GSK2126458 is a highly selective inhibitor for PI3K and mTOR, which could reduce PIPK II β activity by affecting PI3K/Akt/mTOR signaling. | ||||||
IPI 145 | 1201438-56-3 | sc-488318 | 5 mg | $317.00 | ||
IPI-145 is an inhibitor of PI3Kδ and PI3Kγ, which might reduce PIPK II β activity indirectly by altering the PI3K/Akt pathway. | ||||||