Molecular structure of AS-252424, CAS Number: 900515-16-4
AS-252424 (CAS 900515-16-4)
Alternate Names:
5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione
Application:
AS-252424 is a selective PI 3-kinase p110γ inhibitor
CAS Number:
900515-16-4
Purity:
>98%
Molecular Weight:
305.28
Molecular Formula:
C14H8FNO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AS-252424 is a potent and selective PI 3-kinase p110gamma inhibitor (IC50 = 33 nM) shown to be selective for class IB PI 3-kinase-mediated cellular effects. AS-252424 also prevents C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50 of 0.23 muM. AS-252424 is an inhibitor of Casein Kinase and PI 3-kinase p110 alpha.
AS-252424 (CAS 900515-16-4) References
- Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. | Pomel, V., et al. 2006. J Med Chem. 49: 3857-71. PMID: 16789742
- Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform. | Kim, S., et al. 2007. Blood. 110: 4206-13. PMID: 17827385
- Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells. | Heller, R., et al. 2008. Cardiovasc Res. 80: 96-105. PMID: 18558630
- Phosphoinositide 3-kinase mediated signaling in lobster olfactory receptor neurons. | Corey, EA., et al. 2010. J Neurochem. 113: 341-50. PMID: 20132480
- Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms. | Conte, E., et al. 2011. PLoS One. 6: e24663. PMID: 21984893
- Key role of PI3Kγ in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration. | Fougerat, A., et al. 2012. Br J Pharmacol. 166: 1643-53. PMID: 22251152
- Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca(2+)](i), I(Ca), and Ca(2+) transients in HL-1 cardiomyocytes. | Graves, BM., et al. 2012. J Biomed Sci. 19: 59. PMID: 22715995
- Phosphoinositide-3-kinases p110α and p110β mediate S phase entry in astroglial cells in the marginal zone of rat neocortex. | Müller, R., et al. 2013. Front Cell Neurosci. 7: 24. PMID: 23504389
- Phosphoinositide 3-kinase β, phosphoinositide 3-kinase δ, and phosphoinositide 3-kinase γ mediate the anti-inflammatory effects of magnesium sulfate. | Lee, PY., et al. 2015. J Surg Res. 197: 390-7. PMID: 25972311
- Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth. | Sweetlove, M., et al. 2015. Front Oncol. 5: 135. PMID: 26137449
- Potency and pharmacokinetics of broad spectrum and isoform-specific p110γ and δ inhibitors in cancers. | Setti, A., et al. 2016. J Recept Signal Transduct Res. 36: 26-36. PMID: 26791581
- Phosphoinositide 3-Kinase Is Involved in Mediating the Anti-inflammation Effects of Vasopressin. | Jan, WC., et al. 2017. Inflammation. 40: 435-441. PMID: 27943011
- The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation. | Chiu, H., et al. 2017. Front Immunol. 8: 747. PMID: 28713374
- RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gαi2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway. | Lian, X., et al. 2018. Front Physiol. 9: 1234. PMID: 30233409
- Phosphoproteomics Identifies PI3K Inhibitor-selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance. | Cintas, C., et al. 2021. Mol Cancer Ther. 20: 2433-2445. PMID: 34552006
Inhibitor of:
6430550D23Rik, 9430015G10Rik9, AA416372, Casein Kinase, Centaurin α2, Enzyme, GRP1, LAT, Olr639, PI 3-kinase C2α, PI 3-kinase C2β, PI 3-kinase C2y, PI 3-kinase p110 alpha, PI 3-kinase p110 gamma, PIP2, PIPK I β, PIPK II α, PIPK II β, PP2B-B1, Ser/Thr Protein Kinase, and Type II 5-phosphatase.Activator of:
MAP-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AS-252424, 1 mg | sc-202961 | 1 mg | $42.00 | |||
AS-252424, 5 mg | sc-202961A | 5 mg | $158.00 |