PI 3-kinase p110 gamma Inhibitors
Items 11 to 20 of 23 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PI 3-Kγ Inhibitor | 648450-29-7 | sc-203191 | 5 mg | $76.00 | ||
PI 3-Kγ Inhibitor is a highly selective compound targeting the p110 gamma isoform of PI3-kinase, known for its unique interaction with the enzyme's active site. This inhibitor stabilizes a specific conformation that alters substrate accessibility, effectively modulating the enzyme's activity. Its reaction kinetics reveal a gradual inhibition pattern, which can lead to sustained alterations in cellular signaling pathways, impacting various metabolic processes and cellular responses. | ||||||
AS-605240 | 648450-29-7 | sc-221272 sc-221272A | 1 mg 5 mg | $23.00 $80.00 | 1 | |
AS-605240 is a selective inhibitor of the p110 gamma isoform of PI3-kinase, characterized by its ability to disrupt the enzyme's lipid-binding domain. This compound exhibits unique binding dynamics, leading to conformational changes that hinder phosphoinositide substrate recognition. Its kinetic profile suggests a slow-onset inhibition, allowing for prolonged modulation of downstream signaling cascades, which can influence cellular metabolism and immune responses. | ||||||
AS-252424 | 900515-16-4 | sc-202961 sc-202961A | 1 mg 5 mg | $41.00 $155.00 | ||
AS-252424 is a potent and selective inhibitor of PI3Kγ. It competes with ATP for binding to the active site of the kinase, inhibiting downstream signaling pathways involved in inflammation and immune response. | ||||||
LY 294002, 4′-NH2 | 942289-87-4 | sc-203121 sc-203121A | 5 mg 50 mg | $357.00 $2040.00 | 1 | |
LY 294002, 4′-NH2, is a potent inhibitor of the p110 gamma isoform of PI3-kinase, distinguished by its specific interactions with the enzyme's active site. This compound alters the enzyme's conformation, effectively blocking substrate access and disrupting lipid metabolism pathways. Its unique reaction kinetics reveal a competitive inhibition mechanism, which can lead to significant alterations in cellular signaling networks, impacting various physiological processes. | ||||||
AS 041164 | 1146702-72-8 | sc-291912 sc-291912A | 1 mg 5 mg | $23.00 $65.00 | ||
AS 041164 is a selective inhibitor of the p110 gamma isoform of PI3-kinase, characterized by its ability to bind to the enzyme's regulatory domain. This binding induces conformational changes that hinder the phosphorylation of downstream targets, thereby modulating key signaling pathways. The compound exhibits unique kinetic properties, demonstrating a non-competitive inhibition profile that influences cellular responses and metabolic regulation, highlighting its role in fine-tuning cellular homeostasis. | ||||||
PIK-93 | 593960-11-3 | sc-364588 | 5 mg | $255.00 | ||
PIK-93 is a selective inhibitor targeting the p110 gamma isoform of PI3-kinase, known for its unique interaction with the enzyme's ATP-binding site. This interaction alters the enzyme's conformation, effectively disrupting its catalytic activity. PIK-93 exhibits a distinct kinetic behavior, characterized by a mixed inhibition pattern, which influences the phosphorylation dynamics of various substrates. Its specificity for p110 gamma underscores its potential to modulate intricate cellular signaling networks. | ||||||
PIK-75, hydrochloride | 372196-77-5 | sc-296089 sc-296089A | 1 mg 5 mg | $28.00 $122.00 | ||
PIK-75, hydrochloride is a selective inhibitor of the p110 gamma isoform of PI3-kinase, distinguished by its ability to bind to the enzyme's allosteric site. This binding induces conformational changes that hinder substrate access, thereby modulating enzymatic activity. PIK-75 demonstrates unique reaction kinetics, exhibiting competitive inhibition that affects downstream signaling pathways. Its specificity for p110 gamma allows for targeted manipulation of cellular processes, highlighting its role in fine-tuning metabolic responses. | ||||||
TG100-115 | 677297-51-7 | sc-364634 sc-364634A | 5 mg 100 mg | $245.00 $1836.00 | 1 | |
TG100-115 is a dual inhibitor of PI3Kγ and casein kinase 2 (CK2). Its mode of action involves disrupting PI3Kγ signaling and modulating CK2 activity, potentially leading to anti-inflammatory effects. This compound's dual targeting could offer unique therapeutic opportunities in diseases involving immune response and inflammation. | ||||||
BAG 956 | 853910-02-8 | sc-291923 sc-291923A | 10 mg 50 mg | $215.00 $906.00 | ||
BAG 956 is a selective inhibitor of the p110 gamma isoform of PI3-kinase, characterized by its unique ability to interact with the enzyme's active site, leading to a reduction in catalytic efficiency. This compound exhibits distinct kinetic properties, including a non-competitive inhibition profile that alters the enzyme's affinity for substrates. By selectively modulating p110 gamma activity, BAG 956 influences various intracellular signaling cascades, showcasing its potential to impact cellular metabolism and function. | ||||||
XL-147 derivative 1 | 1349796-36-6 | sc-364660 sc-364660A | 5 mg 50 mg | $189.00 $1725.00 | ||
XL-147 derivative 1 is a selective inhibitor targeting the p110 gamma isoform of PI3-kinase, distinguished by its unique binding interactions that stabilize the enzyme in an inactive conformation. This compound exhibits a remarkable ability to disrupt lipid kinase activity, influencing downstream signaling pathways. Its kinetic profile reveals a mixed inhibition mechanism, affecting both substrate binding and turnover rates, thereby modulating cellular responses with precision. | ||||||