LY 294002, 4prime-NH2 CAS: 942289-87-4
MF: C19H18N2O3
MW: 322.36
A PI 3-kinase inhibitor.

LY 294002, 4′-NH2 (CAS 942289-87-4)

LY 294002, 4′-NH2 | CAS 942289-87-4 is rated 5.0 out of 5 by 1.
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Alternate Names: PI 828
Application: LY 294002, 4′-NH2 is a PI 3-kinase inhibitor
CAS Number: 942289-87-4
Purity: >98%
Molecular Weight: 322.36
Molecular Formula: C19H18N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

LY 294002, 4′-NH2 is a cell permeable 4′-amino derivative which inhibits the p110α, p110β, p110δ, and p110γ subunits of PI 3-kinase. LY 294002, 4′-NH2 functions by preventing the phosphorylation of Akt1 in the PI 3-kinase/Akt1/mTOR pathway. In addition, the 4′ end of LY 294002, 4′-NH2 can be immobilized on an epoxy containing solid surface, which is beneficial for binding studies. Moreover, studies suggest that LY 294002, 4′-NH2 interacts with non-PI 3-kinase cellular proteins such as mTOR, ALDH1, Brd4, GSK3β and CKIIα. Another useful characteristic of LY 294002, 4′-NH2 is that it functions as a reversible inhibitor of PI 3-kinase.


References

1. Huang, M., et al. 2003. J. Pharmacol. Exp. Ther. 304: 753-760. PMID: 12538831
2. Saleh, S.N., et al. 2009. J. Physiol. 587: 5361-5375. PMID: 19770190
3. Moriguchi, A., et al. 2010. Circ. J. 74: 2393-2402. PMID: 20877127

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at 4° C
Boiling Point :
~534.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
PI 3-kinase p110β: IC50 = 0.10 µM; PI 3-kinase p110α: IC50 = 0.18 µM; PI 3-kinase p110δ: IC50 = 0.23 µM; PI 3-kinase p110γ: IC50 = 1.97 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25181195
MDL Number :
MFCD11100185
SMILES :
C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=C(C=C4)N

Download SDS (MSDS)

Certificate of Analysis

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LY 294002, 4prime-NH2 (CAS 942289-87-4)  Product Citations

See how others have used LY 294002, 4prime-NH2 (CAS 942289-87-4). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 9636168  Scheid, MP. et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 7439-7444.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Scheid Scheid, MP. et al. (PubMed 9636168) used LY 294002 (4'-NH2), a PI3K inhibitor, to confirm that activation of PKB depends on the activity of PI3K. Cells incubated with LY 294002 were able to completely block PKB activation, even in the presence of activating cytokines. -SCBT Publication Review
Date published: 2015-01-30
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