LY 294002, 4′-NH2 is a cell permeable 4′-amino derivative which inhibits the p110α, p110β, p110δ, and p110γ subunits of PI 3-kinase. LY 294002, 4′-NH2 functions by preventing the phosphorylation of Akt1 in the PI 3-kinase/Akt1/mTOR pathway. In addition, the 4′ end of LY 294002, 4′-NH2 can be immobilized on an epoxy containing solid surface, which is beneficial for binding studies. Moreover, studies suggest that LY 294002, 4′-NH2 interacts with non-PI 3-kinase cellular proteins such as mTOR, ALDH1, Brd4, GSK3β and CKIIα. Another useful characteristic of LY 294002, 4′-NH2 is that it functions as a reversible inhibitor of PI 3-kinase.
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See how others have used LY 294002, 4prime-NH2 (CAS 942289-87-4). Click on the entry to view the PubMed entry .
PMID: # 9636168 Scheid, MP. et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 7439-7444.
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