Molecular structure of BAG 956, CAS Number: 853910-02-8
BAG 956 (CAS 853910-02-8)
Alternate Names:
2-Methyl-2-[4-(2-methyl-8-pyridin-3-ylethynyl-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile
Application:
BAG 956 is a dual PDK1 and class I PI 3-kinase inhibitor
CAS Number:
853910-02-8
Purity:
≥99%
Molecular Weight:
427.50
Molecular Formula:
C28H21N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A dual PDK1 and class I PI3K inhibitor (IC50 values are 245, 56, 446, 35 and 117 nM for PDK1 and PI3K p110 -α, -β, -δ, and -γ respectively). Has been shown to inhibit cellular AKT phosphorylation at Thr308. Also blocks cell proliferation, causing arrest in G1 phase of the cell cycle. Slows tumor progression in mouse xenograft models.
BAG 956 (CAS 853910-02-8) References
Stauffer et al (2008) Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway. Bioorg.Med.Chem.Lett. 18 1027. Weisberg et al (2008) Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells. Blood 111 3723. Marone et al (2009) Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors. Mol.Cancer Res. 7 601.Inhibitor of:
PDK1, PI 3-kinase p110 alpha, PI 3-kinase p110 beta, PI 3-kinase p110 delta, and PI 3-kinase p110 gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAG 956, 10 mg | sc-291923 | 10 mg | $215.00 | |||
BAG 956, 50 mg | sc-291923A | 50 mg | $906.00 |