Molecular structure of PI 3-Kγ Inhibitor, CAS Number: 648450-29-7
PI 3-Kγ Inhibitor (CAS 648450-29-7)
Alternate Names:
5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione, PI 3-K Inhibitor I
Application:
PI 3-Kγ Inhibitor is a cell-permeable, potent, selective, and ATP-competitive inhibitor of PI 3-kinase
CAS Number:
648450-29-7
Purity:
>90%
Molecular Weight:
257.3
Molecular Formula:
C12H7N3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable thiazolidinedione compound that acts as a potent, selective, and ATP-competitive inhibitor of phosphatidylinositol 3-kinase g (PI 3-Kg) (Ki = 7.8 nM; IC50 = 8 nM, 60 nM, 270 nM, 300 nM for p110-g, a, b and d-isoforms, respectively). Does not affect the activity of a wide panel of kinases, receptors, enzymes, and ion channels even at concentrations as high as 1 µM. Selectively blocks MCP-1-, but not CSF-1-, dependent Akt phosphorylation and chemotaxis in primary Pik3cg+/+ murine monocytes and in a human monocytic cell line THP-1 (IC50 = 181 nM). Also shown to exhibit in vivo efficacy in reducing neutrophil chemotaxis in murine peritonitis and arthritis models.
Inhibitor of:
β-defensin 20, β-defensin 21, β-defensin 22, β-defensin 26, Cbl-b, Clm3, EG546901, Enzyme, GIMAP2, IFIT5, KIAA1377, LHPP, mGluR-7, PI 3-kinase p110 alpha, PI 3-kinase p110 beta, PI 3-kinase p110 delta, PI 3-kinase p110 gamma, PIPK I γ, PIPK II γ, Sprouty 4, TMEM55B, TPIP, TTF2, and Vmn2r63.Activator of:
C030019I05Rik, C030030A07Rik, IL-13, IRS-4, MAP-1B, and MTMR2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PI 3-Kγ Inhibitor, 5 mg | sc-203191 | 5 mg | $76.00 |