Molecular structure of AS 041164, CAS Number: 1146702-72-8
AS 041164 (CAS 1146702-72-8)
Alternate Names:
5-(1,3-benzodioxol-5-ylmethylene)-2,4-thiazolidinedione
Application:
AS 041164 is a potent inhibitor of PI 3-kinase
CAS Number:
1146702-72-8
Molecular Weight:
249.2
Molecular Formula:
C11H7NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS 041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS 041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS 041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.
AS 041164 (CAS 1146702-72-8) References
1 Hirsch, E., Ciraolo, E., Ghigo, A., et al. Taming the PI3K team to hold inflammation and cancer at bay. Pharmacology & Therapeutics 118 192-205 (2008). 2 Ferrandi, C., Ardissone, V., Ferro, P., et al. Phosphoinositide 3-kinase γ inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. JPET 322 923-930 (2007).Inhibitor of:
Enzyme, PI 3-kinase p110 alpha, and PI 3-kinase p110 gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AS 041164, 1 mg | sc-291912 | 1 mg | $23.00 | |||
AS 041164, 5 mg | sc-291912A | 5 mg | $65.00 |