PI 3-kinase p110 delta Inhibitors
Phosphoinositide 3-kinase p110δ (PI3Kδ) inhibitors form a distinct chemical class meticulously crafted to selectively target and impede the activity of the p110δ isoform within the phosphoinositide 3-kinase (PI3K) signaling pathway. This signaling cascade serves as a linchpin in cellular communication, functioning as a conduit for transmitting signals from cell surface receptors to intracellular targets. The PI3K pathway's influence extends across diverse cellular processes, intricately regulating phenomena such as cell growth, survival, and metabolism.
The mechanism of action of PI3Kδ inhibitors hinges on their precision targeting of the p110δ isoform within the PI3K enzyme. These inhibitors are designed to disrupt the catalytic activity of PI3Kδ, impeding its ability to phosphorylate phosphoinositide substrates. This targeted interference has the ability to modulate the PI3K signaling pathway, exerting influence over downstream signaling cascades that orchestrate various cellular responses. Ongoing research dedicated to PI3Kδ inhibitors is committed to unraveling the intricate mechanisms that govern their actions, emphasizing a nuanced understanding of PI3K signaling and its multifaceted role in cellular physiology. The exploration of PI3Kδ inhibitors contributes substantively to the scientific understanding of the complex regulatory mechanisms governing cellular signaling pathways.
Items 1 to 10 of 22 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 is a selective inhibitor targeting the p110 delta isoform of PI 3-kinase, known for its unique ability to modulate lipid signaling pathways. It interacts with the enzyme through specific hydrophobic pockets and forms critical hydrogen bonds with amino acid residues, altering the enzyme's conformation. This compound exhibits a distinct kinetic behavior, characterized by a non-competitive inhibition pattern, which provides insights into the dynamics of cellular signaling and metabolic regulation. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $211.00 | 8 | |
BEZ235 is a potent dual inhibitor of PI3K and mTOR, exhibiting a unique mechanism of action through its interaction with the p110 delta isoform. It binds selectively to the ATP-binding site, inducing conformational changes that disrupt enzyme activity. This compound demonstrates a distinct affinity for specific lipid substrates, influencing downstream signaling pathways. Its kinetic profile reveals a mixed inhibition pattern, providing a nuanced understanding of cellular growth and survival mechanisms. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $33.00 $131.00 | 3 | |
PI-103 is a selective inhibitor targeting the p110 delta isoform of PI3-kinase, characterized by its ability to modulate lipid signaling pathways. It engages in specific interactions with the enzyme's active site, leading to alterations in substrate binding dynamics. The compound exhibits unique reaction kinetics, displaying competitive inhibition that fine-tunes cellular responses. Its distinct molecular interactions contribute to the regulation of various cellular processes, highlighting its role in signaling cascades. | ||||||
IC-87114 | 371242-69-2 | sc-364509 sc-364509A | 5 mg 50 mg | $140.00 $1060.00 | 1 | |
IC-87114 is a highly selective inhibitor of the p110 delta isoform of PI3-kinase, known for its unique ability to disrupt lipid metabolism and signaling pathways. It binds with high affinity to the enzyme's active site, influencing conformational changes that affect substrate accessibility. The compound demonstrates a distinct kinetic profile, exhibiting non-competitive inhibition, which alters downstream signaling cascades and cellular functions. Its specific molecular interactions play a crucial role in modulating cellular responses. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
PP242 is a potent inhibitor of the p110 delta isoform of PI3-kinase, characterized by its ability to selectively target and modulate the enzyme's activity. It engages in specific interactions with the enzyme's regulatory domains, leading to altered phosphorylation states of key substrates. This compound exhibits a unique mechanism of action, influencing cellular signaling pathways and metabolic processes through its distinct binding kinetics and allosteric effects, ultimately reshaping cellular behavior. | ||||||
CAL-101 | 870281-82-6 | sc-364453 | 10 mg | $193.00 | 4 | |
CAL-101 is a selective inhibitor of the p110 delta isoform of PI3-kinase, known for its unique ability to disrupt lipid kinase activity. It interacts with the enzyme's active site, leading to a reduction in phosphatidylinositol 3,4,5-trisphosphate levels. This modulation affects downstream signaling cascades, particularly those involved in immune cell function. Its distinct binding affinity and kinetic profile allow for precise regulation of cellular responses, influencing various biological processes. | ||||||
BKM120 | 944396-07-0 | sc-364437 sc-364437A sc-364437B sc-364437C | 5 mg 10 mg 25 mg 50 mg | $176.00 $235.00 $281.00 $339.00 | 9 | |
BKM120 is a selective inhibitor targeting the p110 delta isoform of PI3-kinase, characterized by its unique binding dynamics that alter enzyme conformation. This compound effectively modulates the phosphorylation of inositol lipids, impacting key signaling pathways. Its interaction with the enzyme promotes a shift in reaction kinetics, leading to altered cellular metabolism and growth regulation. BKM120's specificity for p110 delta highlights its role in fine-tuning cellular signaling networks. | ||||||
GDC-0941 | 957054-30-7 | sc-364498 sc-364498A | 5 mg 10 mg | $188.00 $199.00 | 2 | |
GDC-0941 is a selective inhibitor of the p110 delta isoform of PI3-kinase, distinguished by its ability to disrupt the enzyme's active site through unique molecular interactions. This compound influences the phosphorylation cascade of phosphoinositides, thereby modulating downstream signaling pathways. Its kinetic profile reveals a distinct mechanism of action, promoting a nuanced alteration in cellular responses and metabolic processes, underscoring its specificity for p110 delta in cellular signaling modulation. | ||||||
GSK2126458 | 1086062-66-9 | sc-364503 sc-364503A | 2 mg 10 mg | $265.00 $1050.00 | ||
GSK2126458 is a highly selective inhibitor targeting the p110 delta isoform of PI3-kinase, characterized by its unique binding affinity that alters the enzyme's conformation. This compound effectively interferes with lipid metabolism by modulating the production of phosphatidylinositol phosphates, leading to distinct alterations in cellular signaling dynamics. Its interaction with the enzyme's regulatory domains highlights its role in fine-tuning immune responses and cellular growth pathways. | ||||||
GDC-0980 | 1032754-93-0 | sc-364499 sc-364499A | 5 mg 50 mg | $347.00 $1428.00 | ||
GDC-0980 is a potent inhibitor of the p110 delta isoform of PI3-kinase, distinguished by its ability to disrupt the enzyme's active site through specific molecular interactions. This compound exhibits unique kinetics, influencing the phosphorylation of downstream targets and altering metabolic pathways. Its selective binding profile allows for precise modulation of cellular processes, impacting signal transduction and metabolic regulation in various cellular contexts. | ||||||