GDC-0980 CAS: 1032754-93-0
MF: C23H30N8O3S
MW: 498.6
A PI3K and FRAP (mTOR) kinase inhibitor.

GDC-0980 (CAS 1032754-93-0)

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Synonym: RG7422; GNE 390
Application: A PI3K and FRAP (mTOR) kinase inhibitor
CAS Number: 1032754-93-0
Molecular Weight: 498.6
Molecular Formula: C23H30N8O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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GDC-0980 selectively inhibits the activities against class I PI3K and mTOR kinase with a Ki of 17 nM for mTOR (FRAP) and IC50 of 5 nM, 27 nM, 7 nM, and 14 nM for PI3Kα, β, δ, and γ, respectively. GDC-0980 significantly inhibits cell proliferation in PC3 and MCF7 cells.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
Storage :
Store at -20° C
Melting Point :
222-226° C
Boiling Point :
~718.6° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
PI 3-kinase p110α: IC50 = 4.8 nM (human); PI 3-kinase p110 δ: IC50 = 6.7 nM (human); PI 3-kinase p110γ: IC50 = 14 nM (human); PI 3-kinase p110β: IC50 = 27 nM (human); Syk: IC50 = 134 nM (human)
Ki Data :
mTOR: Ki= 17 nM (human)
pK Values :
pKa: 13.9 (Predicted), pKb: 5.03 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25254071
MDL Number :
MFCD20274520
SMILES :
CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[[email protected]](C)O

Download SDS (MSDS)

Certificate of Analysis

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